CASTLE tumor of the parotid: First documented case, literature review, and genetic analysis of the cancer
| Autor: | Laurent Muller, Alexandar Tzankov, Nora Tetter, Eugene Hung Chih Wong |
|---|---|
| Přispěvatelé: | University Hospital Basel [Basel], University of Basel (Unibas), Caractéristiques féminines des dysfonctions des interfaces cardio-vasculaires (EA 2992), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.medical_treatment genetic analysis [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery carcinoma Risk Assessment 03 medical and health sciences 0302 clinical medicine Rare Diseases stomatognathic system Carcinoma medicine Humans Parotid Gland Genetic Testing Neoplasms Glandular and Epithelial carcinoma showing thymus-like elements (CASTLE) biology business.industry CD117 Thyroid Biopsy Needle Cancer Neck dissection Thymus Neoplasms Middle Aged medicine.disease Prognosis Immunohistochemistry Magnetic Resonance Imaging 3. Good health Parotid gland Parotid Neoplasms Radiation therapy 030104 developmental biology medicine.anatomical_structure Treatment Outcome Otorhinolaryngology parotid thymus-like differentiation 030220 oncology & carcinogenesis biology.protein Neck Dissection Female Differential diagnosis business |
| Zdroj: | Archives of Otorhinolaryngology-Head & Neck Surgery Archives of Otorhinolaryngology-Head & Neck Surgery, JAMA Network-American Medical Association, 2018, 40 (1), pp.E1-E4. ⟨10.1002/hed.24985⟩ |
| ISSN: | 2168-6181 2168-619X |
| DOI: | 10.1002/hed.24985⟩ |
| Popis: | International audience; BACKGROUND:Carcinoma showing thymus-like elements (CASTLE) is a rare tumor that normally affects the thyroid gland and was thought to arise from either the remnants of the branchial pouch or the ectopic cervical thymic tissue. These tumors show strong immunopositivity for CD5, P63, and CD117. Most CASTLE of the thyroid gland is treated with surgery with or without adjuvant radiotherapy or chemotherapy.METHOD:A 55-year-old woman presented with a slow-growing right parotid mass. A right total parotidectomy and ipsilateral selective neck dissection were performed and the diagnosis of CASTLE was made after confirmation with an immunohistochemistry test. She received radiotherapy postoperatively.RESULTS:Genetic sequencing showed alterations in the PPARG, BRCA2, and NOTCH1 genes. She remained disease free for >1 year after treatment.CONCLUSION:We believe that this is the first reported case of CASTLE in the parotid gland. Clinicians should be aware of this rare entity and consider this differential diagnosis after ruling out other common parotid lesions. |
| Databáze: | OpenAIRE |
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