Efficacy and safety of a 12-week outpatient pulmonary rehabilitation program in Post-PE Syndrome
| Autor: | J. J. Abbink, Gudula J. A. M. Boon, Maarten K. Ninaber, Lilian J. Meijboom, Steffi Janssen, Martijn A. Spruit, Hubert W. Vliegen, Esther J. Nossent, Petr Symersky, Lucia J.M. Kroft, Waleed Ghanima, Anton Vonk Noordegraaf, Harm Jan Bogaard, Bob Siegerink, Frederikus A. Klok, Stefano Barco, Menno V. Huisman |
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| Přispěvatelé: | University of Zurich, Klok, Frederikus A, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Radiology and nuclear medicine, Cardio-thoracic surgery, Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Quality of life
LIMITATIONS medicine.medical_specialty Hypertension Pulmonary medicine.medical_treatment 2720 Hematology 610 Medicine & health GUIDELINES FATIGUE Pulmonary hypertension Deconditioning QUALITY-OF-LIFE Internal medicine DIAGNOSTIC MANAGEMENT Outpatients medicine Humans Pulmonary rehabilitation Endarterectomy VENOUS THROMBOEMBOLISM Rehabilitation HYPERTENSION business.industry ENDARTERECTOMY 10031 Clinic for Angiology Pulmonary embolism Hematology EMBOLISM medicine.disease Dyspnea Embolism Chronic Disease VOLUME Exercise Test business |
| Zdroj: | Thrombosis Research, 206, 66-75. Elsevier Limited Boon, G J A M, Janssen, S M J, Barco, S, Bogaard, H J, Ghanima, W, Kroft, L J M, Meijboom, L J, Ninaber, M K, Nossent, E J, Spruit, M A, Symersky, P, Vliegen, H W, Noordegraaf, A V, Huisman, M V, Siegerink, B, Abbink, J J & Klok, F A 2021, ' Efficacy and safety of a 12-week outpatient pulmonary rehabilitation program in Post-PE Syndrome ', Thrombosis Research, vol. 206, pp. 66-75 . https://doi.org/10.1016/j.thromres.2021.08.012 Thrombosis Research, 206, 66-75. Elsevier Science Thrombosis Research, 206, 66-75. PERGAMON-ELSEVIER SCIENCE LTD |
| ISSN: | 0049-3848 |
| DOI: | 10.5167/uzh-206434 |
| Popis: | BACKGROUND The Post-Pulmonary Embolism Syndrome (PPES) comprises heterogeneous entities, including chronic thromboembolic disease with/without pulmonary hypertension (CTEPH/CTEPD), and deconditioning. OBJECTIVES To assess underlying physiological determinants of PPES, and efficacy and safety of rehabilitation training in these patients. METHODS 56 consecutive PE patients with persistent dyspnea and/or functional limitations despite ≥3 months of anticoagulation underwent standardized diagnostic work-up including exercise testing as part of routine practice. All diagnostic (imaging and cardiopulmonary function) tests were interpreted by a core group of experienced clinicians. A subgroup of patients without CTEPH or other treatable conditions was referred for a 12-week personalized rehabilitation program, studying changes in physical condition and patient-reported outcome measures. RESULTS Persistent vascular occlusions were observed in 21/56 patients (38%) and CTEPH was confirmed in ten (18%). Regarding those without CTEPH, impaired cardiopulmonary responses were evident in 18/39 patients with available CPET data (46%), unrelated to chronic thrombi. Rehabilitation was completed by 27 patients after excluding 29 (patients with CTEPH or treatable comorbidities, refusal, ineligibility, or training elsewhere). Training intensity, PE-specific quality of life (PEmb-QoL) and fatigue (CIS) improved with a median difference of 20 W (p = 0.001), 3.9 points (p |
| Databáze: | OpenAIRE |
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