Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis
| Autor: | Ludmila Paskova, Idolo Tedesco, Katarína Bauerová, Karol Svik, František Bilka, Gian Luigi Russo, Concetta Gardi, Silvester Ponist, Lukas Slovak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Antioxidants Arthritis Green tea polyphenols Inflammation Methotrexate media_common.quotation_subject Green Tea Polyphenols Oxidative phosphorylation Pharmacology 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) media_common 030109 nutrition & dietetics business.industry Monocyte food and beverages medicine.disease medicine.anatomical_structure Polyphenol Rheumatoid arthritis business Adjuvant arthritis 030217 neurology & neurosurgery Food Science medicine.drug |
| Zdroj: | PharmaNutrition 14 (2020). doi:10.1016/j.phanu.2020.100228 info:cnr-pdr/source/autori:Ponist, Silvester; Gardi, Concetta; Paskova, Ludmila; Svik, Karol; Slovak, Lukas; Bilka, Frantisek; Tedesco, Idolo; Bauerova, Katarina; Russo, Gian Luigi/titolo:Modulation of methotrexate efficacy by green tea polyphenols in rat adjuvant arthritis/doi:10.1016%2Fj.phanu.2020.100228/rivista:PharmaNutrition/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume:14 |
| DOI: | 10.1016/j.phanu.2020.100228 |
| Popis: | Background Green tea catechins are widely employed as dietary supplements to restore the oxidative state in adjuvant-induced arthritic rats, a model for human rheumatoid arthritis. Methotrexate is the first line antirheumatic drug. The present study aimed to investigate if a decaffeinated extract (GreenSelect®, GS) of tea polyphenols can ameliorate methotrexate treatment in rat adjuvant arthritis. Methods The study lasted 28 days and included healthy animals administered with GS (daily dose of 200 mg/kg), untreated arthritic rats and arthritic rats treated with: GS, methotrexate in single treatment or in combination with GS. Arthritic score and changes in body weigh were measured during the treatment while inflammatory markers (monocyte chemotactic protein-1, IL-17 and inducible NO-synthase mRNA) and biochemical parameters (gamma-glutamyltransferase and heme oxygenase-1) at the end of the treatment. Results The association between GS and methotrexate was less efficient in ameliorating the arthritic score compared to methotrexate alone. GS did not improve the inflammatory and biochemical markers except for monocyte chemotactic protein-1 and negatively affected the body weight. GS did not increase the plasma antioxidant capacity, suggesting a pro-oxidant effect. Conclusions The results suggest that long-term administration of GS may inhibit the therapeutic action of methotrexate in arthritic rats. |
| Databáze: | OpenAIRE |
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