Occupational Exposure to Solvents and the Risk of Lymphomas

Autor: Luciano Romeo, Letizia Sommani, Giulio Andrea Tozzi, Paolo Crosignani, Stefania Rodella, Vanessa Bolejack, Loredana Troschel, Giuseppe Miceli, Valerio Ramazzotti, Isabella Belletti, Alessandra Benvenuti, Dino Amadori, Adele Seniori Costantini, Igino Mendico, Emanuele Stagnaro, David Kriebel, Dario Mirabelli, Lucia Miligi, Rosario Tumino, Paolo Vineis
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
BENZENE
Epidemiology
UNITED-STATES
Hydrocarbons
Aromatic
POOLED ANALYSIS
Occupational medicine
NON-HODGKINS-LYMPHOMA
CHRONIC LYMPHOCYTIC-LEUKEMIA
MULTICENTER CASE-CONTROL
C VIRUS-INFECTION
CANCER INCIDENCE
POOLED ANALYSIS
UNITED-STATES
FOLLOW-UP
BENZENE
WORKERS
Risk Factors
immune system diseases
Occupational Exposure
hemic and lymphatic diseases
Hydrocarbons
Chlorinated
medicine
Humans
NON-HODGKINS-LYMPHOMA
Risk factor
Aged
CHRONIC LYMPHOCYTIC-LEUKEMIA
business.industry
MULTICENTER CASE-CONTROL
Developed Countries
Lymphoma
Non-Hodgkin
Case-control study
WORKERS
Middle Aged
medicine.disease
Hodgkin Disease
Leukemia
Lymphocytic
Chronic
B-Cell
Dermatology
Lymphoma
Surgery
Pooled analysis
Italy
Cancer incidence
Multicenter study
CANCER INCIDENCE
Case-Control Studies
Solvents
Female
Occupational exposure
FOLLOW-UP
business
C VIRUS-INFECTION
Zdroj: Epidemiology. 17:552-561
ISSN: 1044-3983
DOI: 10.1097/01.ede.0000231279.30988.4d
Popis: A number of studies have shown possible associations between occupational exposures, particularly solvents, and lymphomas. The present investigation aimed to evaluate the association between exposure to solvents and lymphomas (Hodgkin and non-Hodgkin) in a large population-based, multicenter, case-control study in Italy.All newly diagnosed cases of malignant lymphoma in men and women age 20 to 74 years in 1991-1993 were identified in 8 areas in Italy. The control group was formed by a random sample of the general population in the areas under study stratified by sex and 5-year age groups. We interviewed 1428 non-Hodgkin lymphoma cases, 304 Hodgkin disease cases, and 1530 controls. Experts examined the questionnaire data and assessed a level of probability and intensity of exposure to a range of chemicals.Those in the medium/high level of exposure had an increased risk of non-Hodgkin lymphoma with exposure to toluene (odds ratio = 1.8; 95% confidence interval = 1.1-2.8), xylene 1.7 (1.0-2.6), and benzene 1.6 (1.0-2.4). Subjects exposed to all 3 aromatic hydrocarbons (benzene, toluene, and xylene; medium/high intensity compared with none) had an odds ratio of 2.1 (1.1-4.3). We observed an increased risk for Hodgkin disease for those exposed to technical solvents (2.7; 1.2-6.5) and aliphatic solvents (2.7; 1.2-5.7).This study suggests that aromatic and chlorinated hydrocarbons are a risk factor for non-Hodgkin lymphomas, and provides preliminary evidence for an association between solvents and Hodgkin disease.
Databáze: OpenAIRE
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