Consumption of -glucans to spice up T cell treatment of tumors: a review
| Autor: | Harry J. Wichers, Coen Govers, Priscilla de Graaff, Reno Debets |
|---|---|
| Přispěvatelé: | Medical Oncology |
| Rok vydání: | 2018 |
| Předmět: |
beta-Glucans
T cell T-Lymphocytes Clinical Biochemistry Spice Administration Oral Biology Immunotherapy Adoptive 03 medical and health sciences Mice 0302 clinical medicine Adjuvants Immunologic Neoplasms Drug Discovery medicine Tumor Microenvironment Animals Humans innate immunity Objective response VLAG Food Health & Consumer Research Pharmacology Consumption (economics) Innate immune system pattern recognition receptors Pattern recognition receptor Adoptive T cell therapy Combined Modality Therapy Health & Consumer Research medicine.anatomical_structure Food 030220 oncology & carcinogenesis Immunology β-glucans 030215 immunology |
| Zdroj: | Expert Opinion on Biological Therapy, 18(10), 1023-1040. Taylor & Francis Ltd Expert Opinion on Biological Therapy, 18(10), 1023-1040 Expert Opinion on Biological Therapy 18 (2018) 10 |
| ISSN: | 1744-7682 1471-2598 |
| Popis: | Introduction: Adoptive T-cell treatments of solid cancers have evolved into a robust therapy with objective response rates surpassing those of standardized treatments. Unfortunately, only a limited fraction of patients shows durable responses, which is considered to be due to a T cell-suppressive tumor microenvironment (TME). Here we argue that naturally occurring β-glucans can enable reversion of such T cell suppression by engaging innate immune cells and enhancing numbers and function of lymphocyte effectors. Areas covered: This review summarizes timely reports with respect to absorption, trafficking and immune stimulatory effects of β-glucans, particularly in relation to innate immune cells. Furthermore, we list effects toward well-being and immune functions in healthy subjects as well as cancer patients treated with orally administered β-glucans, extended with effects of β-glucan treatments in mouse cancer models. Expert opinion: Beta-glucans, when present in food and following uptake in the proximal gut, stimulate immune cells present in gut-associated lymphoid tissue and initiate highly conserved pro-inflammatory pathways. When tested in mouse cancer models, β-glucans result in better control of tumor growth and shift the TME toward a T cell-sensitive environment. Along these lines, we advocate that intake of β-glucans provides an accessible and immune-potentiating adjuvant when combined with adoptive T-cell treatments of cancer. |
| Databáze: | OpenAIRE |
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