PCOS and pregnancy: a review of available therapies to improve the outcome of pregnancy in women with polycystic ovary syndrome
| Autor: | Claudia Sergiampietri, Maria Elena Rosa Obino, Paolo Giovanni Artini, Elena Casarosa, Francesca Papini, Sara Pinelli, Vito Cela |
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| Rok vydání: | 2018 |
| Předmět: |
Assisted reproductive techniques
clomiphene citrate infertility treatments insulin sensitizing agents polycystic ovary syndrome Endocrinology Diabetes and Metabolism medicine.medical_specialty 030209 endocrinology & metabolism 03 medical and health sciences Endocrinology 0302 clinical medicine Pregnancy Humans Medicine Obesity 030219 obstetrics & reproductive medicine Infertility treatments business.industry Obstetrics Female infertility Pregnancy Outcome Fertility Agents Female medicine.disease Polycystic ovary Diabetes and Metabolism Female Laparoscopy business Infertility Female Anovulation |
| Zdroj: | Expert Review of Endocrinology & Metabolism. 13:87-98 |
| ISSN: | 1744-8417 1744-6651 |
| DOI: | 10.1080/17446651.2018.1431122 |
| Popis: | Polycystic ovary syndrome (PCOS) is a common cause of female infertility affecting multiple aspects of a women's health.The aim of this review is to summarize the existing evidence on the treatment of PCOS patients and to examine the actual available therapies to overcome the problem of infertility and improve the outcome of pregnancy. We analyse different treatment strategies such as lifestyle modification, bariatric surgery, insulin sensitizing agents, inositol, clomiphene citrate (CC), aromatase inhibitors, gonadotrophins, laparoscopic ovarian drilling, and assisted reproductive techniques (ART).Lifestyle modification is the best initial management for obese PCOS patients seeking pregnancy and insulin sensitizing agents seem to have an important role in treating insulin resistance. Up to now, CC maintains a central role in the induction of ovulation and it has been confirmed as the first-line treatment; the use of gonadotrophins is considered the second-line in CC resistant patients; laparoscopic ovarian drilling is an alternative to gonadotrophins in patients who need laparoscopy for another reason. However, in anovulatory patients, ART represents the only possible alternative to obtain pregnancy. Larger and well-designed studies are needed to clarify the best way to improve the outcome of pregnancy in PCOS women. |
| Databáze: | OpenAIRE |
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