The protection of primates against soman poisoning by pretreatment with pyridostigmine
| Autor: | Mary C. French, P Dirnhuber, L. Leadbeater, D. M. Green, June A. Stratton |
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| Rok vydání: | 1979 |
| Předmět: |
Atropine
Male Time Factors Soman Pharmaceutical Science Pharmacology Organophosphate poisoning Median lethal dose Lethal Dose 50 chemistry.chemical_compound Organophosphate Poisoning medicine Animals Cholinesterases business.industry Haplorhini medicine.disease Macaca mulatta Pyridostigmine chemistry Callitrichinae Female business Pyridostigmine Bromide medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 31:295-299 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1979.tb13504.x |
| Popis: | The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 μg kg−1, i.v.) raised the subcutaneous LD50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. Theprotection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. These levels of protection are higher than any reported in non-primate species. |
| Databáze: | OpenAIRE |
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