Proton pump inhibitor intake negatively affects the osseointegration of dental implants: a retrospective study
| Autor: | Nelli Yıldırımyan, Burak Kocabalkan, Alper Sindel, Öznur Özalp, Mehmet Ali Altay |
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| Rok vydání: | 2019 |
| Předmět: |
Proton pump inhibitors
medicine.drug_class medicine.medical_treatment Population Dentistry Proton-pump inhibitor Osseointegration 03 medical and health sciences 0302 clinical medicine Medicine 030223 otorhinolaryngology Dental implant education education.field_of_study Dental implantation business.industry Rehabilitation Implant failure Retrospective cohort study 030206 dentistry Exact test Risk factors Original Article Surgery Implant Oral Surgery business |
| Zdroj: | Journal of the Korean Association of Oral and Maxillofacial Surgeons |
| ISSN: | 2234-5930 2234-7550 |
| DOI: | 10.5125/jkaoms.2019.45.3.135 |
| Popis: | Objectives This study sought to investigate the association between the systemic intake of proton pump inhibitors (PPI) and the early failure of dental implants. Materials and methods A retrospective cohort study involving 1,918 dental implants in 592 patients (69 implants in 24 PPI users and 1,849 implants in 568 nonusers, respectively) was conducted. The effect of PPI intake on the osseointegration of dental implants was evaluated using patient- and implant-level models. Results Among 24 PPI users, two patients experienced implant failure, one of whom had three and the other of whom had one failed implant, respectively. Thus, the rate of failure for this population was 8.3%. Separately, 11 nonusers each experienced one implant failure, and the failure rate for these patients was 1.9%. Fisher's exact test revealed statistically significant differences between PPI users and nonusers at the implant level (P=0.002) but failed to show any significance at the patient level (P=0.094). The odds of implant failure were 4.60 times greater among PPI users versus nonusers. Dental implants that were placed in patients using PPIs were found to be 4.30 times more likely to fail prior to loading. Conclusion The findings of this study suggest that PPI intake may be associated with an increased risk of early dental implant failure. |
| Databáze: | OpenAIRE |
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