Screening as a strategy to drive regenerative medicine research
| Autor: | Jan de Boer, Steven Vermeulen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
OSTEOGENIC DIFFERENTIATION
Computer science Biocompatible Materials HIGH-THROUGHPUT SURFACE-ROUGHNESS Regenerative Medicine Regenerative medicine General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Incomplete knowledge Extensive data Molecular Biology GENE-EXPRESSION 030304 developmental biology SUBSTRATE TOPOGRAPHY 0303 health sciences Tissue Engineering BACTERIAL ATTACHMENT 030302 biochemistry & molecular biology COMBINATORIAL DEVELOPMENT MICROFLUIDIC PLATFORM Cell Differentiation 3. Good health PROGENITOR CELLS Biochemical engineering EMBRYONIC STEM-CELLS Design space |
| Zdroj: | Methods |
| ISSN: | 1046-2023 |
| Popis: | In the field of regenerative medicine, optimization of the parameters leading to a desirable outcome remains a huge challenge. Examples include protocols for the guided differentiation of pluripotent cells towards specialized and functional cell types, phenotypic maintenance of primary cells in cell culture, or engineering of materials for improved tissue interaction with medical implants. This challenge originates from the enormous design space for biomaterials, chemical and biochemical compounds, and incomplete knowledge of the guiding biological principles. To tackle this challenge, high-throughput platforms allow screening of multiple perturbations in one experimental setup. In this review, we provide an overview of screening platforms that are used in regenerative medicine. We discuss their fabrication techniques, and in silico tools to analyze the extensive data sets typically generated by these platforms. |
| Databáze: | OpenAIRE |
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