Clinical Value of Combined Detection of CK-MB, MYO, cTnI and Plasma NT-proBNP in Diagnosis of Acute Myocardial Infarction
| Autor: | Haiju Liu, Ji Ma, Bao-an Li, Jiubo Fan, Ning Xia, Li Sun |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Heart disease medicine.drug_class Myocardial Infarction General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Natriuretic Peptide Brain Troponin I medicine Natriuretic peptide Creatine Kinase MB Form Humans cardiovascular diseases Myocardial infarction Creatine Kinase health care economics and organizations Coronary atherosclerosis biology Myoglobin business.industry medicine.disease Peptide Fragments chemistry 030220 oncology & carcinogenesis biology.protein Clinical value Cardiology Creatine kinase business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Clinical Laboratory. 63 |
| ISSN: | 1433-6510 |
| DOI: | 10.7754/clin.lab.2016.160533 |
| Popis: | Background Acute myocardial infarction (AMI) is a serious life-threatening and common heart disease that is based on coronary atherosclerosis. The aim is to study the changes in the level of kinase isoenzyme (CK-MB), myoglobin (MYO), cardiac troponin I (cTnI), and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with acute myocardial infarction (AMI) and the four indicators of joint detection clinical value for diagnosis of AMI. Methods Plasma NT-proBNP, CK-MB, MYO, and cTnI were detected by CLIA in 208 AMI patients (AMI group) and 115 non-AMI patients (control group). SPSS 19.0 software was used to analyze the data. Results The concentrations of CK-MB, MYO, cTnI, and NT-proBNP show significant differences between these two groups. In the AMI group, a significantly positive correlation was found between CK-MB and each of MYO and cTnI (r = 0.537, r = 0.226). Meanwhile, the sensitivity of combined detection has been improved up to 92.79%. Conclusions Therefore, these results suggested that detecting CK-MB, MYO, cTnI, and plasma NT-proBNP levels together can significantly contribute to the early diagnosis of AMI. It can also provide diagnostic evidence to clinic and thus lower the mortality of AMI in acute phase. |
| Databáze: | OpenAIRE |
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