SUN proteins and nuclear envelope spacing
| Autor: | Daniel A. Starr, Natalie E. Cain |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Nesprin
biology Nuclear Envelope LINC complex Extra View UNC-84 Nuclear Proteins Cell Biology biology.organism_classification KASH protein Membrane SUN protein Biophysics Inner membrane nesprin Animals Humans Disease Generic health relevance Nuclear protein Lamin Caenorhabditis elegans Envelope (waves) |
| Zdroj: | Nucleus Cain, NE; & Starr, DA. (2015). SUN proteins and nuclear envelope spacing. Nucleus, 6(1), 2-7. doi: 10.4161/19491034.2014.990857. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4mp239mv Nucleus (Austin, Tex.), vol 6, iss 1 |
| ISSN: | 1949-1042 1949-1034 |
| DOI: | 10.4161/19491034.2014.990857. |
| Popis: | © Natalie E Cain and Daniel A Starr. The nuclear envelope consists of 2 membranes separated by 30–50 nm, but how the 2 membranes are evenly spaced has been an open question in the field. Nuclear envelope bridges composed of inner nuclear membrane SUN proteins and outer nuclear membrane KASH proteins have been proposed to set and regulate nuclear envelope spacing. We tested this hypothesis directly by examining nuclear envelope spacing in Caenorhabditis elegans animals lacking UNC-84, the sole somatic SUN protein. SUN/KASH bridges are not required to maintain even nuclear envelope spacing in most tissues. However, UNC-84 is required for even spacing in body wall muscle nuclei. Shortening UNC-84 by 300 amino acids did not narrow the nuclear envelope space. While SUN proteins may play a role in maintaining nuclear envelope spacing in cells experiencing forces, our data suggest they are dispensable in most cells. |
| Databáze: | OpenAIRE |
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