Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model

Autor:	Daniel E. Rivera, Núria M. Pastor-Soler, Pei-Yin Ho, Valeria Mancino, Jessica Pham, Hui Li, Biagio Saitta, Kenneth R. Hallows
Rok vydání:	2022
Předmět:	Male medicine.medical_specialty Mice 129 Strain TRPP Cation Channels Time Factors endocrine system diseases Physiology Autosomal dominant polycystic kidney disease Mice Transgenic Disease Kidney Renal Agents urologic and male genital diseases Kidney cysts Internal medicine medicine Animals Genetic Predisposition to Disease Gene Cell Proliferation PKD1 urogenital system business.industry nutritional and metabolic diseases AMPK Polycystic Kidney Autosomal Dominant medicine.disease Metformin female genital diseases and pregnancy complications Mice Inbred C57BL Disease Models Animal Endocrinology medicine.anatomical_structure Mutation Disease Progression Kidney Failure Chronic Female Inflammation Mediators medicine.symptom business Glomerular Filtration Rate medicine.drug
Zdroj:	American Journal of Physiology-Renal Physiology. 322:F27-F41
ISSN:	1522-1466 1931-857X
Popis:	Metformin treatment improved ADPKD disease severity in a relevant, slowly progressive ADPKD mouse model that recapitulates a PKD-associated PKD1 mutation. Relative to controls, metformin reduced kidney weight/body weight, cystic index and BUN levels, while improving GFR, blood pressure and anemia. Metformin also reduced key inflammatory and injury markers, along with cell proliferation markers. These findings suggest several beneficial effects of metformin in this ADPKD mouse model, which may help inform new ADPKD therapies in patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6dccc29424ebb85640e27d51af32b6 https://doi.org/10.1152/ajprenal.00298.2021 Zobrazit plný text záznamu