The safety and tolerability of zolpidem — an update
| Autor: | D. Pringuey, G. Darcourt, J. Lavoisy, D. Sallière |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Zolpidem Pyridines medicine.drug_class Pharmacology GABAergic Agonist Hypnotic 03 medical and health sciences 0302 clinical medicine Sleep Initiation and Maintenance Disorders Animals Humans Hypnotics and Sedatives Medicine Pharmacology (medical) Hypnotic Effects business.industry 030227 psychiatry Psychiatry and Mental health Tolerability Sedative business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 13:81-93 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/026988119901300109 |
| Popis: | Zolpidem belongs to a new class of hypnotic agents, chemically distinct from the pre-existing ones, and has a unique neuropharmacological profile. It induces sedative/hypnotic effects in rodents at doses much lower than those for anticonvulsant and myorelaxant activities. Clinically, zolpidem is indicated for the short term treatment of insomnia. It has a short half-life (2.4 h), with no active metabolite, and does not accumulate during repeated administration. The pharmacokinetic profile associated with the absence of active metabolites is consistent with the short duration of action and absence of residual effects that have been observed. Polysomnographic experience indicates that zolpidem induces a sleep pattern which is similar to that of physiological sleep, and which produces either no or only minimal effects on sleep architecture after abrupt discontinuation. Aspects of the general safety of zolpidem have been studied in data obtained from healthy volunteers and patients, both adult and elderly, during its clinical development and in post-marketing experience. Zolpidem appears to be well-tolerated in adults and in the elderly, when administered in accordance with prescribing instructions. The available data indicate that, in these circumstances, the risk of abuse or dependence is minimal. |
| Databáze: | OpenAIRE |
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