Comparison of inter- and intra-chromosomal aberrations in blood samples exposed to different dose rates of gamma radiation
| Autor: | R.K. Jeevanram, Solomon F. D. Paul, Mary N. Mohankumar, B. Karthikeya-Prabhu, Perumal Venkatachalam, K. Muthuvelu, M. B. David |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
In Vitro Techniques Radiation Chromosome aberration Healthy volunteers Chromosomes Human Humans Double minute Radiology Nuclear Medicine and imaging Lymphocytes Irradiation Chromosome Aberrations Radiological and Ultrasound Technology Chemistry business.industry Public Health Environmental and Occupational Health Chromosome Chromosome Breakage Dose-Response Relationship Radiation General Medicine Peripheral blood Blood Gamma Rays Nuclear medicine business Dose rate |
| Zdroj: | Radiation Protection Dosimetry. 103:103-109 |
| ISSN: | 1742-3406 0144-8420 |
| DOI: | 10.1093/oxfordjournals.rpd.a006120 |
| Popis: | Peripheral blood samples obtained from a normal healthy volunteer were exposed in vitro to gamma radiation with various doses at different dose rates of 1.0, 0.1 and 0.0014 Gy min(-1). The exposed samples were analysed for different chromosomal aberrations such as dicentrics (DC), centric rings (CR) and double-minutes (DM). The ratio of DC chromosomes (inter) to the total number of centric rings (CR) and double-minutes (DM) (CR + DM = intra) were analysed for all the three dose rates. The study showed that the frequency of inter-arm chromosomal aberrations was more then three times higher than that observed with intra-arm chromosomal aberrations in samples exposed at a dose rate of 1.0 and 0.1 Gy min (-1). However, the frequency of inter- and intra-arm chromosomal aberrations were almost same (ratio 1:1) in samples exposed at a dose rate of 0.0014 Gy min(-1). This paper discusses the usefulness of the ratio of inter- and intra-arm chromosome aberration in finding out whether the sample was exposed to high or low dose rate radiation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|