Effect of late-onset epilepsy on cognitive functioning in patients with small vessel disease
| Autor: | Estevo Santamarina, Marc Turon, Manuel Toledo, Laura Abraira, José Alvarez-Sabín, Manuel Quintana, Joan Jiménez-Balado, Pilar Delgado, Olga Maisterra, Elena Fonseca, Xavier Salas-Puig |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Epilepsy Recall business.industry Cognition Audiology Verbal learning medicine.disease Behavioral Neuroscience Cross-Sectional Studies Neurology medicine Humans Dementia Cognitive Dysfunction Neurology (clinical) Cognitive skill Verbal memory business Neurocognitive Retrospective Studies |
| Zdroj: | Epilepsy & Behavior. 123:108238 |
| ISSN: | 1525-5050 |
| DOI: | 10.1016/j.yebeh.2021.108238 |
| Popis: | Late-onset epilepsy (LOE) often has underlying cerebrovascular cause and has been associated with neurocognitive deficits and dementia. Nevertheless, the interplay between these factors has not been studied thus far. Hence, we conducted a retrospective cross-sectional study aimed to explore how unprovoked epileptic seizures along with vascular-related factors contribute to neurocognitive impairments in patients with cerebral small vessel disease.Twenty-seven patients with LOE aged 60 years with concomitant cerebral small vessel disease (cSVD) and a matched group of cSVD without epilepsy were cognitively assessed. Demographic, clinical, and vascular information were obtained and vascular burden score was calculated for each patient. Multiple linear regression models were used to explore the relationship between epilepsy and cognitive measures adjusting for demographic and vascular risk factors.Compared with cSVD, cSVD-LOE group showed a poorer performance on verbal memory measures, visuomotor tracking and speed processing and phonetic fluency. In the multiple regression analysis, the presence of epilepsy was found to be the major predictor for verbal memory dysfunction, specifically in verbal short recall (p = 0.008) and verbal learning (p 0.001). No interactions between vascular burden and epilepsy were found.Patients who had cSVD with concurrent LOE showed poorer performance on memory function compared with patients with cSVD without epilepsy, and they showed a different cognitive profile from that typically manifested by patients with cSVD. The presence of epilepsy, but not seizure localization nor vascular burden, was the major contributor to the decrease in verbal memory. |
| Databáze: | OpenAIRE |
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