Extended Nitric Oxide-Releasing Polyurethanes via S-Nitrosothiol-Modified Mesoporous Silica Nanoparticles
| Autor: | Mark H. Schoenfisch, Maggie J Malone-Povolny |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Materials science Kinetics technology industry and agriculture Nanoparticle 02 engineering and technology Polymer Mesoporous silica 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Article 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering General Materials Science Thermal stability Leaching (metallurgy) 0210 nano-technology Porosity Polyurethane |
| Zdroj: | ACS Applied Materials & Interfaces. 11:12216-12223 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.8b19236 |
| Popis: | S-nitrosothiol (RSNO)-modified mesoporous silica nanoparticles (MSNs) were doped into polyurethane (PU) to achieve extended NO-releasing coatings. Parameters influencing the synthesis of RSNO-functionalized nitric oxide (NO)-releasing MSNs were evaluated to elucidate the impact of pore structure on NO-release characteristics. The porous particles were characterized as having larger NO payloads and longer NO-release durations than that of nonporous particles, a feature attributed to recombination of the NO radical in confined intraporous microenvironments. Nitric oxide-release kinetics, particle leaching, and thermal stability of the RSNO-modified MSNs dispersed in PU were evaluated as a function of PU structure to determine the feasibility of preparing a range of NO-releasing polymers for biomedical device coating applications. The NO-release kinetics from the PUs proved to be highly extended (>30 d) and consistent over a range of polyurethane properties. Furthermore, RSNO-modified MSN leaching was not observed from the PUs. The NO-release payloads were also maintained for 4 days for polymers stored at 0 °C. |
| Databáze: | OpenAIRE |
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