Studies on Dieffenbachia picta Schott: Toxic effects in guinea pigs
| Autor: | Paulo Sawaya, Sylvia O. Andrade, Ângela M. Ladeira |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Chlorpheniramine
Time Factors Guinea Pigs Calcium oxalate In Vitro Techniques Toxicology Promethazine Araceae Lethal Dose 50 Guinea pig chemistry.chemical_compound Ileum Botany Animals Chymotrypsin Centrifugation Incubation Plant Proteins Pharmacology biology Traditional medicine Plant Extracts Muscle Smooth biology.organism_classification Plants Toxic chemistry biology.protein Dieffenbachia Histamine Muscle Contraction |
| Zdroj: | Toxicology and Applied Pharmacology. 34:363-373 |
| ISSN: | 0041-008X |
| DOI: | 10.1016/0041-008x(75)90132-5 |
| Popis: | The toxic activity of some Araceae species (containing calcium oxalate) used in popular medicine is described, as well as a series of tests with Dieffenbachia picta Schott done to estimate the toxic activity of this species of Araceae in the guinea pig. Administration of D. picta juices orally to the guinea pig showed that the toxic component (LD50 between 600 and 900 mg of stem/animal in 24 hr) is contained in the stem and is unstable on heating to 100°C or on vacuum drying at 50–60°C. Administration of chlorpheniramine or incubation of the juice with chymotrypsin did not hinder edema formation in the mouths of test animals. Stem juice is also toxic when injected ip (LD50, 1 g) but not when administered directly into the stomach by intubation. Only the precipitate of the stem juice obtained by centrifugation at 3°C, 10,000 rpm for 1 hr, but not the supernate, contains the toxic component. The supernate contains one substance that causes contraction of smooth musculature; it is probably not histamine, since dosing with an antihistamic compound (promethazine) did not inhibit its effect. Leaves also contain this component, but do not exhibit any toxic effect when tested orally in animals. No nitrogen was detected in the residue of the stem juice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|