Inactivation of Voltage-Gated Cardiac K + Channels
| Autor: | Shuguang Liu, Randall L. Rasmusson, Donald L. Campbell, Mulugu V. Brahmajothi, Shaomeng Wang, Michael J. Morales, Harold C. Strauss |
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| Rok vydání: | 1998 |
| Předmět: |
Membrane potential
Potassium Channels Voltage-gated ion channel Physiology Chemistry Kinetics Heart Depolarization Peptide Fragments Membrane Potentials Electrophysiology Allosteric Regulation Biochemistry Biophysics Biophysical Process Animals Humans Cardiology and Cardiovascular Medicine Ion Channel Gating Intracellular Ion channel Protein Binding |
| Zdroj: | Circulation Research. 82:739-750 |
| ISSN: | 1524-4571 0009-7330 |
| Popis: | Abstract —Inactivation is the process by which an open channel enters a stable nonconducting conformation after a depolarizing change in membrane potential. Inactivation is a widespread property of many different types of voltage-gated ion channels. Recent advances in the molecular biology of K + channels have elucidated two mechanistically distinct types of inactivation, N-type and C-type. N-type inactivation involves occlusion of the intracellular mouth of the pore through binding of a short segment of residues at the extreme N-terminal. In contrast to this “tethered ball” mechanism of N-type inactivation, C-type inactivation involves movement of conserved core domain residues that result in closure of the external mouth of the pore. Although C-type inactivation can show rapid kinetics that approach those observed for N-type inactivation, it is often thought of as a slowly developing and slowly recovering process. Current models of C-type inactivation also suggest that this process involves a relatively localized change in conformation of residues near the external mouth of the permeation pathway. The rate of C-type inactivation and recovery can be strongly influenced by other factors, such as N-type inactivation, drug binding, and changes in [K + ] o . These interactions make C-type inactivation an important biophysical process in determining such physiologically important properties as refractoriness and drug binding. C-type inactivation is currently viewed as arising from small-scale rearrangements at the external mouth of the pore. This review will examine the multiplicity of interactions of C-type inactivation with N-terminal–mediated inactivation and drug binding that suggest that our current view of C-type inactivation is incomplete. This review will suggest that C-type inactivation must involve larger-scale movements of transmembrane-spanning domains and that such movements contribute to the diversity of kinetic properties observed for C-type inactivation. |
| Databáze: | OpenAIRE |
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