The effect of lovastatin on early restenosis
| Autor: | N. Zafrir, D. Gavish, Y. Teplitzky, Y. Neuman, Y. Beigel, M. Fainaru, M. Wurzel |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Percutaneous medicine.medical_treatment Hypercholesterolemia Coronary Disease Placebo Coronary Angiography Asymptomatic Restenosis Double-Blind Method Recurrence Internal medicine Angioplasty medicine Humans Pharmacology (medical) cardiovascular diseases Lovastatin Prospective Studies Angioplasty Balloon Coronary Prospective cohort study Aged Pharmacology business.industry Incidence Cholesterol LDL Middle Aged medicine.disease Surgery surgical procedures operative medicine.anatomical_structure Cardiology Exercise Test medicine.symptom business medicine.drug Artery |
| Zdroj: | Journal of clinical pharmacology. 35(6) |
| ISSN: | 0091-2700 |
| Popis: | The effect of lovastatin given before percutaneous coronary angioplasty (PTCA) on early restenosis was investigated in men with mild to moderate hypercholesterolemia. Thirty-four hypercholesterolemic patients (serum LDL cholesterol 130-200 mg/dL) undergoing their first PTCA completed a 6-month prospective, double-blind, placebo-controlled trial. Eighteen received lovastatin 20 mg/day (Lo group) and 16 placebo (P1 group), beginning 10 to 21 days before PTCA. All underwent a thallium-201 quantitative exercise test 5 to 7 days after PTCA. Endpoints for restenosis were either 50% narrowing of the dilated artery on coronary angiography, performed in symptomatic patients or, in asymptomatic patients, the appearance of newly developed reversible filling defects in the vascular territory of the dilated artery on a second thallium scan done 6 months after PTCA. The hypocholesterolemic change observed in the Lo group was not accompanied by a reduction in early restenosis risk. The authors conclude that effective hypocholesterolemic therapy before PTCA does not affect early restenosis rate in men with mild to moderate hypercholesterolemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text