In vivo investigation of antihyperalgesic and antinociceptive effects of peat formulations
| Autor: | Elisaveta G. Apostolova, Julian Borisov Lukanov, Bissera Pilicheva, Plamen Zagorchev, Vesela Kokova, Milena N Draganova-Filipova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Peat Diclofenac Time Factors Acrylic Resins Pharmaceutical Science Carrageenan peat hyperalgesia Wistar rats 03 medical and health sciences Soil 0302 clinical medicine In vivo Receptors Adrenergic alpha-2 medicine Animals Cyclooxygenase Inhibitors Hot plate test Rats Wistar Pharmaceutical industry Pharmacology Analgesics Chromatography Cyclooxygenase 2 Inhibitors Chemistry wistar rats General Medicine Rats Disease Models Animal Nociception 030220 oncology & carcinogenesis Hyperalgesia medicine.symptom HD9665-9675 Gels 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta Pharmaceutica, Vol 68, Iss 3, Pp 373-380 (2018) Acta Pharmaceutica Volume 68 Issue 3 |
| ISSN: | 1846-9558 1330-0075 |
| Popis: | The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan-induced hyperalgesia, combined with a test with a mechanical stimulus, and a hot plate test. Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme, respectively. Carbopol gel, Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls. Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment. In the hot plate test, the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour. The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity. |
| Databáze: | OpenAIRE |
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