New Studies of Pathogenesis of Rheumatoid Arthritis with Collagen-Induced and Collagen Antibody-Induced Arthritis Models: New Insight Involving Bacteria Flora
| Autor: | Takaki Waritani, Ryoichi Hashida, Yasunori Shimozuru, Jessica Chang, Ibis Agosto-Marlin, Kuniaki Terato |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Arthritis Review Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Immunology and Microbiology (miscellaneous) Flora (microbiology) medicine Immunology and Allergy 030203 arthritis & rheumatology biology business.industry RC581-607 medicine.disease biology.organism_classification 030104 developmental biology Rheumatoid arthritis Collagen antibody induced arthritis Immunologic diseases. Allergy business Dysbiosis Bacteria |
| Zdroj: | Autoimmune Diseases Autoimmune Diseases, Vol 2021 (2021) |
| ISSN: | 2090-0422 |
| Popis: | Much public research suggests that autoimmune diseases such as rheumatoid arthritis (RA) are induced by aberrant “self” immune responses attacking autologous tissues and organ components. However, recent studies have reported that autoimmune diseases may be triggered by dysbiotic composition changes of the intestinal bacteria and an imbalance between these bacteria and intestinal immune systems. However, there are a few solid concepts or methods to study the putative involvement and relationship of these inner environmental factors in RA pathogenesis. Fortunately, Collagen-Induced Arthritis (CIA) and Collagen Antibody-Induced Arthritis (CAIA) models have been widely used as animal models for studying the pathogenesis of RA. In addition to RA, these models can be extensively used as animal models for studying complicated hypotheses in many diseases. In this review, we introduce some basic information about the CIA and CAIA models as well as how to apply these models effectively to investigate relationships between the pathogenesis of autoimmune diseases, especially RA, and the dysbiosis of intestinal bacterial flora. |
| Databáze: | OpenAIRE |
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