RNA interference (RNAi) inhibits growth of Plasmodium falciparum
| Autor: | Louisa McRobert, Glenn A. McConkey |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Messenger RNA
Chorismic Acid Plasmodium falciparum RNA Biology biology.organism_classification Molecular biology Circumsporozoite protein RNA silencing Pyrimidines RNA interference Dihydroorotate dehydrogenase Animals Parasitology RNA Messenger Phosphorus-Oxygen Lyases Oxidoreductases Molecular Biology Gene RNA Double-Stranded |
| Zdroj: | Molecular and Biochemical Parasitology. 119:273-278 |
| ISSN: | 0166-6851 |
| DOI: | 10.1016/s0166-6851(01)00429-7 |
| Popis: | RNA interference (RNAi) causes degradation of targeted endogenous RNA in many diverse organisms. Erythrocyte-infecting stages of the malaria parasite Plasmodium falciparum were treated with double-stranded RNA (dsRNA) encoding a segment of the gene encoding dihydroorotate dehydrogenase (DHODH). DHODH is an enzyme in pyrimidine biosynthesis, essential for parasite growth. A decrease in parasite growth (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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