Palladium-Catalyzed Three-Component Coupling of Ynamides
| Autor: | Youhei Kikuchi, Ayano Takahashi, Yuichi Yoshimura, Madoka Sasaki, Yukako Saito, Yoshihiro Natori, Ayaka Ishii, Hideaki Wakamatsu |
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| Rok vydání: | 2020 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Component (thermodynamics) Ligand Organic Chemistry chemistry.chemical_element Regioselectivity 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis Potassium carbonate chemistry.chemical_compound chemistry Polymer chemistry Coupling (piping) Physical and Theoretical Chemistry Acetonitrile Palladium |
| Zdroj: | Organic Letters. 22:5299-5303 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | A palladium-catalyzed regioselective three-component coupling of ynamides was developed. The reaction proceeded smoothly to furnish the desired products when carried out at 70 °C in acetonitrile/water with potassium carbonate in the presence of 2.5 mol % Pd2(dba)3·CHCl3 without a ligand. Various iodides and boronic acids were used in this reaction, and a carbon-carbon bond was formed with satisfactory regioselectivity from the ynamides. |
| Databáze: | OpenAIRE |
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