p38 Mitogen-activated protein kinase inhibitor SB203580 reverses the antianalgesia induced by dextro-morphine or morphine in the mouse spinal cord
| Autor: | Hsiang-en Wu, Han-Sen Sun, Leon F. Tseng, Caleb W. Cheng |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
MAPK/ERK pathway Pyridines p38 mitogen-activated protein kinases Central nervous system Pharmacology p38 Mitogen-Activated Protein Kinases Article Mice Reaction Time medicine Animals Enzyme Inhibitors Receptor Protein kinase A Pain Measurement Morphine Chemistry Imidazoles Stereoisomerism Spinal cord Analgesics Opioid medicine.anatomical_structure Spinal Cord Opioid medicine.drug |
| Zdroj: | European Journal of Pharmacology. 550:91-94 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/j.ejphar.2006.08.060 |
| Popis: | We have previously demonstrated that intrathecal pretreatment with dextro-morphine or morphine attenuates the morphine-produced antinociception. The phenomenon has been defined as antianalgesia, which is mediated by a non-opioid receptor [Wu, H., Thompson, J., Sun, H., Terashvili, M., Tseng, L.F., 2005. Antianalgesia: stereo-selective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord. J. Pharmacol. Exp. Ther. 314, 1101-1108]. To determine if p38 mitogen-activated protein kinase (MAPK) is involved in the antianalgesia, the effects of p38 MAPK inhibitor 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole (SB203580) on the attenuation of the morphine-produced tail-flick inhibition induced by dextro-morphine or morphine were studied in male CD-1 mice. Intrathecal pretreatment with SB203580 (24.2 nmol) reversed the attenuation of the morphine-produced tail-flick inhibition induced by dextro-morphine (33 fmol) or morphine (0.3 nmol) pretreatment. The finding indicates that the antianalgesia induced by dextro-morphine or morphine is mediated by the activation of p38 MAPK in the mouse spinal cord. |
| Databáze: | OpenAIRE |
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