Association between diabetes status and subsequent onset of glaucoma in postmenopausal women
| Autor: | Da Ran Kim, Kyungdo Han, Jung Ii Moon, Younhea Jung, Kyoung Ohn |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Alcohol Drinking Science medicine.medical_treatment Glaucoma Article Risk Factors Internal medicine Diabetes mellitus medicine Humans Aged Dyslipidemias Multidisciplinary Postmenopausal women business.industry Insulin Hazard ratio Smoking Diabetes Diabetes status Age Factors Middle Aged medicine.disease Impaired fasting glucose Postmenopause Diabetes Mellitus Type 2 Case-Control Studies Hypertension Optic nerve diseases Medicine Female business Dyslipidemia |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The purpose of this study was to analyze the risk of glaucoma based on diabetes status using a large nationwide longitudinal cohort of postmenopausal women. This study included 1,372,240 postmenopausal women aged ≥ 40 years who underwent National Health Screening Program in 2009. Subjects were classified into the following 5 categories based on diabetes status: no diabetes, impaired fasting glucose (IFG), new onset diabetes, diabetes treated with oral hypoglycemic medication, and diabetes treated with insulin. Subjects were followed from 2005 through 2018, and hazard ratios of glaucoma onset were calculated for each group. Subgroup analyses of subjects stratified by age, smoking, drinking, hypertension, and dyslipidemia were performed. During the follow up period, 42,058 subjects developed glaucoma. The adjusted hazard ratio was 1.061 (95% CI, 1.036–1.086) in the IFG group, 1.151 (95% CI, 1.086–1.220) in the new onset diabetes group, 1.449 (95% CI, 1.406–1.493) in the diabetes treated with oral hypoglycemic medication group, and 1.884(95% CI, 1.777–1.999) in the diabetes treated with insulin group compared to the no diabetes group. The results were consistent in subgroup analyses after stratifying by age, lifestyle factors (smoking and drinking), and comorbidities (hypertension and dyslipidemia). Diabetes status is associated with increased risk of glaucoma development in postmenopausal women. |
| Databáze: | OpenAIRE |
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