Hemispheric asymmetry in resting motor threshold in major depression
| Autor: | Alexandra Sporn, Rita Navarro, David H. Avery, Paul Zarkowski |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Central nervous system Neuroscience (miscellaneous) Functional Laterality Statistics Nonparametric Benzodiazepines Internal medicine Linear regression medicine Humans Depression (differential diagnoses) Benzodiazepine Analysis of Variance Depression Motor Cortex Middle Aged Transcranial Magnetic Stimulation Transcranial magnetic stimulation Psychiatry and Mental health medicine.anatomical_structure Sensory Thresholds Laterality Cardiology Linear Models Antidepressant Female Analysis of variance Psychology Neuroscience |
| Zdroj: | The journal of ECT. 25(1) |
| ISSN: | 1533-4112 |
| Popis: | Objectives Previous studies of repetitive transcranial magnetic stimulation suggest a hemispheric imbalance in patients with major depression. These studies report an antidepressant effect by activation of the left prefrontal cortex or inhibition of the right prefrontal cortex. The aim of this study is to investigate interhemispheric differences in cortical excitability in a large sample of patients with major depression. Methods The resting motor threshold (RMT) was measured on 91 patients with treatment-resistant major depression. We controlled for current medication use, gender, age, handedness, and study site. Results There was no significant difference between the left RMT (55.96 [10.356]) and the right (57.74 [11.359]) (P = 0.131, Wilcoxon matched-pairs test). A multivariate analysis found no significant association between depression scores and right or left RMT. After adjusting for important cofactors, benzodiazepine use was found to be a significant predictor of left RMT (P = 0.017, linear regression) and right RMT (P = 0.007, linear regression). Conclusion Our results do not support the existence of an interhemispheric imbalance of cortical excitability in depressed patients. Benzodiazepine use was found to raise both the left and right RMT. |
| Databáze: | OpenAIRE |
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