Effects of exercise training and ACE inhibition on insulin action in rat skeletal muscle
| Autor: | Melanie B. Schmit, Michelle S. Steen, Erik J. Henriksen, Tyson R. Kinnick, Kara R. Foianini, Erik B. Youngblood |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Monosaccharide Transport Proteins Physiology medicine.medical_treatment Biological Transport Active Muscle Proteins Angiotensin-Converting Enzyme Inhibitors Physical exercise Citrate (si)-Synthase Oxygen Consumption Treadmill running Hexokinase Physical Conditioning Animal Physiology (medical) Internal medicine Animals Insulin Medicine Muscle Skeletal Ace inhibition Pancreatic hormone Glucose Transporter Type 4 biology business.industry Body Weight Skeletal muscle Angiotensin-converting enzyme Organ Size Glucose Tolerance Test Rats Rats Zucker Glucose medicine.anatomical_structure Endocrinology Area Under Curve ACE inhibitor biology.protein Female business medicine.drug |
| Zdroj: | Journal of Applied Physiology. 89:687-694 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.2000.89.2.687 |
| Popis: | Our laboratory has demonstrated (Steen MS, Foianini KR, Youngblood EB, Kinnick TR, Jacob S, and Henriksen EJ, J Appl Physiol 86: 2044–2051, 1999) that exercise training and treatment with the angiotensin-converting enzyme (ACE) inhibitor trandolapril interact to improve insulin action in insulin-resistant obese Zucker rats. The present study was undertaken to determine whether a similar interactive effect of these interventions is manifest in an animal model of normal insulin sensitivity. Lean Zucker ( Fa/−) rats were assigned to either a sedentary, trandolapril-treated (1 mg · kg−1· day−1for 6 wk), exercise-trained (treadmill running for 6 wk), or combined trandolapril-treated and exercise-trained group. Exercise training alone or in combination with trandolapril significantly ( P < 0.05) increased peak oxygen consumption by 26–32%. Compared with sedentary controls, exercise training alone or in combination with ACE inhibitor caused smaller areas under the curve for glucose (27–37%) and insulin (41–44%) responses during an oral glucose tolerance test. Exercise training alone or in combination with trandolapril also improved insulin-stimulated glucose transport in isolated epitrochlearis (33–50%) and soleus (58–66%) muscles. The increases due to exercise training alone or in combination with trandolapril were associated with enhanced muscle GLUT-4 protein levels and total hexokinase activities. However, there was no interactive effect of exercise training and ACE inhibition observed on insulin action. These results indicate that, in rats with normal insulin sensitivity, exercise training improves oral glucose tolerance and insulin-stimulated muscle glucose transport, whereas ACE inhibition has no effect. Moreover, the beneficial interactive effects of exercise training and ACE inhibition on these parameters are not apparent in lean Zucker rats and, therefore, are restricted to conditions of insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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