Continuous monitoring of WBC (biochemistry) in an adult leukemia patient using advanced FTIR-spectroscopy
| Autor: | Nir Brosh, Ranjit Sahu, Udi Zelig, Mahmoud Huleihel, Miriam Ben-Harosh, Marina Talyshinsky, Jossi Kapelushnik, Shaul Mordechai |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_treatment Lymphoblastic Leukemia Population Predictive Value of Tests hemic and lymphatic diseases Spectroscopy Fourier Transform Infrared Leukocytes medicine Humans Fourier transform infrared spectroscopy Child education Monitoring Physiologic Chemotherapy education.field_of_study business.industry Remission Induction Adult Acute Myeloid Leukemia Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia Myeloid Acute Leukemia Oncology Biochemistry Evaluation Studies as Topic Child Preschool Female business After treatment |
| Zdroj: | Leukemia Research. 30:687-693 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/j.leukres.2005.10.011 |
| Popis: | Fourier transform infrared (FTIR)-spectroscopy has been found useful for monitoring the effectiveness of drugs during chemotherapy in leukemia patients. In the present work, spectral changes that occurred in the white blood cells (WBC) of an adult acute myeloid leukemia (AML) patient and their possible utilization for monitoring biochemistry of WBC were investigated. The phosphate absorbance from nucleic acids and the lipid-protein ratio in the WBC decreased immediately after treatment and then increased to levels of a control group. Similar observations were recorded in child patients with acute lymphoblastic leukemia (ALL) who were used as test cases. These parameters maybe used as possible markers to indicate successful remission and suggest that FTIR-spectroscopy may provide a rapid optical method for continuous monitoring or evaluation of a WBC population. |
| Databáze: | OpenAIRE |
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