Resting-state mapping of neural signatures of vulnerability to depression relapse
| Autor: | Li-Rong Tang, Meng Li, Lihong Wang, Bin Li, Marie Woelfer, Yue Gao, Walter Martin, Chun-Hong Liu, Guang-Zhong Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Rest Thalamus Gyrus Cinguli 03 medical and health sciences Young Adult 0302 clinical medicine Neuroimaging Recurrence Internal medicine Parietal Lobe medicine Humans Major depressive episode Anterior cingulate cortex Depression (differential diagnoses) Brain Mapping Depressive Disorder Major Resting state fMRI medicine.diagnostic_test business.industry Brain medicine.disease Magnetic Resonance Imaging Temporal Lobe 030227 psychiatry Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Major depressive disorder Female medicine.symptom business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Journal of affective disorders. 250 |
| ISSN: | 1573-2517 |
| Popis: | Background Patients with major depressive disorder (MDD) can frequently develop new depressive episodes after remission. However, the neural mechanisms underlying the increased risk for depressive relapse remain unclear. Herein, we aimed to explore whether the specific changes to regional and inter-regional spontaneous brain activities within DMN are associated with the course of episodes in pooled MDD patients. Methods Resting-state functional magnetic resonance imaging was performed on patients with single-episode MDD (SEMDD, n = 30) and multiple-episode MDD (MEMDD, n = 54), and 71 age-, gender-, and educational level-matched healthy controls (HCs). We then accessed the differences in both the fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity by using the right precuneus as the seed among different groups. Results Compared to the MEMDD and HC groups, the SEMDD group exhibited increased fALFF values in the right subgenual anterior cingulate cortex and right middle temporal gyrus. Decreased fALFF values in the right thalamus in the MEMDD group were also identified relative to the SEMDD and HC group. The peak values of fALFF in the right precuneus showed a negative correlation with the number of depressive episodes across the entire pool of MDD patients. No correlation was identified between functional connectivity using the right precuneus as the seed and the number of depressive episodes for the pooled MDD patients. Limitations Medication, a relatively small sample size, and hypothesis driven study. Conclusions Our neuroimaging results identified depression relapse-associated neural signatures and also indicated the role of reduced emotional appraisals in the thalamus. It is now possible to believe that the regional activity not inter-regional connectivity within the DMN may be involved in the pathology of depression relapse. |
| Databáze: | OpenAIRE |
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