Benzodiazepine partially reverses tonic-clonic seizures induced by thiocolchicoside
| Autor: | D.S. Leitão, A.R. Andrade, N.C.L. Medeiros, M.F.C. Martins, L.O. Ferreira, V.C. Santos, A.O. Hamoy, L.A.L. Barbas, N.A. Muto, V. Jóia de Mello, D.C.F. Lopes, M. Hamoy |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Physiology General Neuroscience Antiepileptic drugs Immunology Biophysics Ocean Engineering Cell Biology General Medicine urologic and male genital diseases Proconvulsive activity Seizure Biochemistry female genital diseases and pregnancy complications Rats Benzodiazepines Seizures Animals Pentylenetetrazole Anticonvulsants Electrocorticography General Pharmacology Toxicology and Pharmaceutics Rats Wistar Colchicine Thiocolchicoside |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 55, Article number: e11771, Published: 28 FEB 2022 Brazilian Journal of Medical and Biological Research v.55 2022 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| ISSN: | 1414-431X |
| Popis: | Seizures are a disorder caused by structural brain lesions, life-threatening metabolic derangements, or drug toxicity. The present study describes the behavior related to proconvulsant activity induced by thiocolchicoside (TCC) in rats and investigates the electrocorticographic patterns of this behavior and the effectiveness of classic antiepileptic drugs used to control these seizures. Forty-nine adult male Wistar rats were used and divided into two phases of our experimental design: 1) evaluation of seizure-related behavior and electrocorticographic patterns induced by TCC and 2) evaluation of the efficacy of classical antiepileptic drugs to control the proconvulsive activity caused by TCC. Our results showed that TCC induced tonic-clonic seizures that caused changes in electrocorticographic readings, characteristic of convulsive activity, with average amplitude greater than that induced by pentylenetetrazole. Treatment with anticonvulsants, especially diazepam, reduced the electrocorticographic outbreaks induced by TCC. The results suggested that TCC caused seizures with increased power in brain oscillations up to 40 Hz and that diazepam may partially reverse the effects. |
| Databáze: | OpenAIRE |
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