Poly(ethylene) glycols and mechanochemistry for the preparation of bioactive 3,5-disubstituted hydantoins
| Autor: | Jean Martinez, M. Dimassi, Laure Konnert, Evelina Colacino, Frédéric Lamaty, Lori Gonnet |
|---|---|
| Přispěvatelé: | Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM) |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Ethylene [CHIM.ORGA]Chemical Sciences/Organic chemistry 010405 organic chemistry General Chemical Engineering Hydantoin General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences 0104 chemical sciences chemistry.chemical_compound Ethotoin chemistry Mechanochemistry medicine [CHIM]Chemical Sciences Organic chemistry Alkyl medicine.drug Poly ethylene |
| Zdroj: | RSC Advances RSC Advances, Royal Society of Chemistry, 2016, 6 (43), pp.36978-36986. ⟨10.1039/c6ra03222b⟩ |
| ISSN: | 2046-2069 |
| Popis: | International audience; Mechanochemistry was effective for the preparation of 3,5-disubstituted hydantoins from a-amino methyl esters, using either 1,1 0-carbonyldiimidazole (CDI) or alkyl isocyanates. The preparation of the antimicrobial additives, 3-allyl-5,5 0-dimethyl hydantoin (ADMH) and 1-chloro-3-ethyl-5,5 0-dimethyl hydantoin (CEDMH) were performed by grinding. A chlorination reaction, never described before by mechanochemistry was achieved by Ca(ClO) 2 , while the preparation of the bioactive anticonvulsant marketed drug ethotoin was achieved by a novel approach based on poly(ethylene) glycol (PEGs) assisted grinding. |
| Databáze: | OpenAIRE |
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