Why Are Viscosity and Nonlinearity Bound to Make an Impact in Clinical Elastographic Diagnosis?
| Autor: | Inas H Faris, Given Names Deactivated Family Name Deactivated, Guillermo Rus, Juan Melchor, Jorge Torres, Antonio Manuel Callejas Zafra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
elastography
Computer science Liver fibrosis Review lcsh:Chemical technology Biochemistry Viscoelasticity 030218 nuclear medicine & medical imaging Analytical Chemistry 03 medical and health sciences Viscosity 0302 clinical medicine Prostate medicine Humans lcsh:TP1-1185 Electrical and Electronic Engineering Instrumentation Nonlinearity viscoelasticity medicine.diagnostic_test Linear elasticity Biomechanics Soft tissue Stiffness nonlinearity Histology Microstructure Atomic and Molecular Physics and Optics Biomechanical Phenomena Nonlinear system medicine.anatomical_structure 030220 oncology & carcinogenesis Elasticity Imaging Techniques Elastography medicine.symptom soft tissue Biomedical engineering |
| Zdroj: | Digibug. Repositorio Institucional de la Universidad de Granada Consejo Superior de Investigaciones Científicas (CSIC) Digibug: Repositorio Institucional de la Universidad de Granada Universidad de Granada (UGR) Sensors (Basel, Switzerland) Sensors, Vol 20, Iss 2379, p 2379 (2020) |
| DOI: | 10.3390/s20082379 |
| Popis: | The contributions by Antonio Gomez, Monica Contreras and Francisca S. Molina are gratefully acknowledged. The adoption of multiscale approaches by the biomechanical community has caused a major improvement in quality in the mechanical characterization of soft tissues. The recent developments in elastography techniques are enabling in vivo and non-invasive quantification of tissues’ mechanical properties. Elastic changes in a tissue are associated with a broad spectrum of pathologies, which stems from the tissue microstructure, histology and biochemistry. This knowledge is combined with research evidence to provide a powerful diagnostic range of highly prevalent pathologies, from birth and labor disorders (prematurity, induction failures, etc.), to solid tumors (e.g., prostate, cervix, breast, melanoma) and liver fibrosis, just to name a few. This review aims to elucidate the potential of viscous and nonlinear elastic parameters as conceivable diagnostic mechanical biomarkers. First, by providing an insight into the classic role of soft tissue microstructure in linear elasticity; secondly, by understanding how viscosity and nonlinearity could enhance the current diagnosis in elastography; and finally, by compounding preliminary investigations of those elastography parameters within different technologies. In conclusion, evidence of the diagnostic capability of elastic parameters beyond linear stiffness is gaining momentum as a result of the technological and imaging developments in the field of biomechanics. This research was funded by Ministerio de Educación, Cultura y Deporte grant numbers DPI2017-83859-R, DPI2014-51870-R, UNGR15-CE-3664 and EQC2018-004508-P; Ministerio de Sanidad, Servicios Sociales e Igualdad grant numbers DTS15/00093 and PI16/00339; Instituto de Salud Carlos III y Fondos Feder; Junta de Andalucía grant numbers PI-0107-2017, PIN-0030-2017 and IE2017-5537; Juan de la Cierva Incorporación IJC2018-037167-I, Ministerio de Ciencia, Innovación y Universidades grant number PRE2018-086085. |
| Databáze: | OpenAIRE |
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