Direct and indirect immunofluorescence staining patterns in the diagnosis of paraneoplastic pemphigus
| Autor: | Gilles F. H. Diercks, Marcel F. Jonkman, J. . Siland, Angelique Poot, Hendrikus Pas |
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| Přispěvatelé: | Translational Immunology Groningen (TRIGR), Microbes in Health and Disease (MHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Envoplakin
Pathology medicine.medical_specialty Paraneoplastic Syndromes EPITHELIUM Dermatology Desmoglein Autoantigens 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Humans Fluorescent Antibody Technique Indirect Periplakin SPECIFICITY Plakin VULGARIS biology Staining and Labeling integumentary system Desmoplakin Plectin medicine.disease Pemphigus Paraneoplastic pemphigus Fluorescent Antibody Technique Direct 030220 oncology & carcinogenesis Immunology biology.protein AUTOANTIBODIES |
| Zdroj: | The British journal of dermatology, 174(4), 912-915. Wiley |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/bjd.14282 |
| Popis: | Paraneoplastic pemphigus (PNP) is a rare but severe multiorgan autoimmune disease that occurs in the presence of an underlying neoplasm. It is clinically characterized by a painful oral stomatitis, and a range of skin eruptions. In PNP, autoantibodies are directed against the intracellular desmosomal and hemidesmosomal plaque proteins of the plakin family: envoplakin, periplakin, desmoplakin, BP230 and plectin. In addition, the desmosomal proteins desmoglein (Dsg) 3 and less frequently Dsg 1 are targeted, as well as the protease inhibitor alpha-2-macroglobulin-like antigen-1 (A2ML1).(1-4) Diagnosing PNP largely depends on the demonstration of these autoantibodies. Immunoblotting and immunoprecipitation are sensitive and specific methods to detect these circulating antibodies. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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