Haploinsufficiency of the MLL and TOB2 genes in lymphoid malignancy

Autor:	Helena Kempski, Qian An, G A A Burke, Jonathan C. Strefford, M Martineau, Adam R. M. Stewart, M Dainton, Zoe J. Konn, David Webb, W Myooren, Christine J. Harrison, Mary Taj
Rok vydání:	2009
Předmět:	Cancer Research medicine.medical_specialty Cell Cycle Proteins Chromosomal translocation Biology Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Loss of heterozygosity Mediator Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Internal medicine medicine Humans Child Hox gene Gene In Situ Hybridization Fluorescence Genetics Hematology Oncogene Infant Histone-Lysine N-Methyltransferase Haplotypes Oncology Cancer research Female Haploinsufficiency Myeloid-Lymphoid Leukemia Protein
Zdroj:	Leukemia. 24:649-652
ISSN:	1476-5551 0887-6924
DOI:	10.1038/leu.2009.238
Popis:	There are many different mechanisms by which the promiscuous MLL gene, with a diversity of partners, can be converted into an oncogene. These include translocations, duplications, insertions and deletions all of which have been linked to HOX gene deregulation as the mediator of haematological malignancy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac514dc375c3c10fa3a90d84d6fc0f44 https://doi.org/10.1038/leu.2009.238 Zobrazit plný text záznamu