Diagnosis of Medullary Carcinoma of the Thyroid (MCT) by Calcitonin Assay Using Monoclonal Antibodies: Criteria for the Pentagastrin Stimulation Test in Hereditary MCT
| Autor: | J. C. Besnard, J. L. Baulieu, P. Lecomte, G. Kaphan, C. Calmettes, R. Perdrisot, G. Milhaud, J. C. Bigorgne, D. Guilloteau, Pierre Jallet |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism Clinical Biochemistry Radioimmunoassay Thyroid Function Tests Biochemistry Thyroid function tests Thyroid carcinoma Endocrinology Internal medicine Biomarkers Tumor medicine Humans Thyroid Neoplasms Aged Immunoradiometric assay medicine.diagnostic_test business.industry Carcinoma Biochemistry (medical) Thyroid Antibodies Monoclonal Middle Aged medicine.disease Pentagastrin medicine.anatomical_structure Medullary carcinoma Female Immunoradiometric Assay business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 71:1064-1067 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem-71-4-1064 |
| Popis: | A new calcitonin (CT) immunoradiometric assay, using anti-11-7 and anti-24-32 CT fragment monoclonal antibodies was evaluated and compared to classical RIA. The sensitivity was 2.5 ng/L, the normal basal level (n = 83) was lower than 10 ng/L, the response to pentagastrin stimulation in control subjects was absent in nine and between 10-30 ng/L in nine others. (mean, 15.4). In patients with renal failure the basal level was increased between 10-52 ng/L. In patients with medullary thyroid carcinoma (MTC; n = 28), the basal level was between 189-28,900 ng/L. A pentagastrin test was performed as screening for familial MTC in eight patients with confirmed MTC at subsequent surgery; the calcitonin peak was equal or greater than 38 ng/L. Large differences exist between CT levels measured by RIA and immunoradiometric assay. The latter method provides a greater sensitivity to pentagastrin test and allows a better identification of microcarcinoma in hereditary cases of MTC. |
| Databáze: | OpenAIRE |
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