Acquisition of Streptococcus pneumoniae and nonspecific morbidity in infants and their families: a cohort study
| Autor: | Derrick W. Crook, Tim E. A. Peto, Ron Dagan, David J. Griffiths, Marion Gardiner, Lesley Daniels, Sunetra Gupta, E. R. Moxon, Jonathan J Deeks, Karen Sleeman |
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| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Microbiology (medical)
Male medicine.medical_specialty Pediatrics medicine.disease_cause Pneumococcal Infections Risk Factors Epidemiology Streptococcus pneumoniae medicine Humans Prospective Studies Prospective cohort study business.industry Hazard ratio Infant Newborn Infant Odds ratio Health Services medicine.disease Pneumococcal infections Infectious Diseases Carriage Pediatrics Perinatology and Child Health Carrier State Female business Cohort study |
| Zdroj: | The Pediatric infectious disease journal. 24(2) |
| ISSN: | 1532-0987 0891-3668 |
| Popis: | BACKGROUND: Most children are believed to acquire Streptococcus pneumoniae asymptomatically, with only a few developing overt S. pneumoniae disease. This study investigates the relationship between acquisition of S. pneumoniae and mild nonspecific infection leading to general practitioner (GP) consultation. METHODS: A prospective birth cohort study of 213 infants assessed at home 9 times during 24 weeks by nasopharyngeal swab and parental interview was conducted. RESULTS: All positive S. pneumoniae swabs (including acquisition and carriage) were significantly associated with GP consultations for infection by the study infant compared with infants with negative swabs [odds ratio (OR), 1.6; 95% confidence interval (CI) 1.1-2.2; P = 0.005]. There was a stronger association with S. pneumoniae acquisition alone (OR 2.1; 95% CI 1.3-3.4; P = 0.001) than with carriage only (OR 1.4; 95% CI 0.9-2.0; P = 0.1). Multivariate analysis confirmed that S. pneumoniae acquisition by the study subject was independently associated with GP consultations: adjusted hazard ratio, 1.8 (95% CI 1.1-2.9); P = 0.02. A similar and independent association was found between S. pneumoniae acquisition by the study subject, and GP consultations for infection by the family (adjusted hazard ratio, 1.8; 95% CI 1.1-2.8; P = 0.01). CONCLUSION: Acquisition of S. pneumoniae by the study infant was significantly associated with GP consultations for infection by the infant or family. |
| Databáze: | OpenAIRE |
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