Coronary or thoracic artery calcium score in provoked and unprovoked pulmonary embolism: a case-control study
| Autor: | Lucia J.M. Kroft, N. van der Bijl, Frederikus A. Klok, A. de Roos, Menno V. Huisman |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty pulmonary embolism Intraclass correlation Aorta Thoracic 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences Thoracic Arteries 0302 clinical medicine thoracic aorta Risk Factors medicine.artery Internal medicine Pulmonary angiography Humans Medicine Thoracic aorta Prospective Studies Aorta Aged Observer Variation business.industry Case-control study Calcinosis computed tomography Hematology Odds ratio Middle Aged medicine.disease Coronary Vessels Confidence interval Pulmonary embolism Coronary arteries Treatment Outcome medicine.anatomical_structure Case-Control Studies Cardiology Calcium Female atherosclerosis Tomography X-Ray Computed business coronary arteries |
| Zdroj: | Journal of Thrombosis and Haemostasis Journal of Thrombosis and Haemostasis, 14(5), 931-935 |
| DOI: | 10.1111/jth.13289 |
| Popis: | UNLABELLED Essentials Patients with unprovoked pulmonary embolism (PE) are at increased risk of arterial thromboembolism. Coronary and thoracic aorta calcium were evaluated in patients with and without (unprovoked) PE. No association was found between (unprovoked) PE and coronary or aortic calcification. Assessment of both calcium scores on computed tomography pulmonary angiography was highly reproducible. SUMMARY Objective To evaluate the potential association between (unprovoked) pulmonary embolism (PE) and the presence and extent of coronary artery calcium (CAC) and thoracic aorta calcium (TAC). Methods CAC and TAC derived from computed tomography pulmonary angiography of 100 patients with PE were compared to that of 100 patients in whom PE was ruled out. Results Intraobserver and interobserver agreements for both TAC and CAC were excellent (intraclass correlation > 0.95 for both). In patients with PE vs. patients without PE, no significant differences were found in the presence of CAC or TAC (CAC 64% vs. 67%, odds ratio [OR] 1.0, 95% confidence interval [CI] 0.67-1.6; TAC 46% vs. 59%, OR 1.2, 95% CI 0.80-2.1). Mean CAC and TAC scores were significantly lower in patients with PE than in patients without PE (CAC 3.4 vs. 4.9, absolute difference 1.5, 95% CI 0.2-2.8; TAC 1.1 vs. 1.8, absolute difference 0.9, 95% CI 0.2-1.2). No significant differences were found in the presence of CAC or TAC or in mean CAC and TAC scores between patients with unprovoked PE vs. patients with provoked PE, or between patients with unprovoked PE vs. no PE. Conclusion No significant differences were found between the extent of CAC and TAC in patients with unprovoked PE compared to those with provoked PE or without PE. The observed difference in the extend of CAC and TAC between patients with and without PE was dependent on prevalent cardiovascular risk factors. |
| Databáze: | OpenAIRE |
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