Break Away: FKBP12 sequestration as a target for increasing BMP activity
| Autor: | Felix Hausch, Martha C. Taubert |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
urogenital system Common disease Clinical Biochemistry Cell Chemical biology Acute kidney injury Treatment options Tacrolimus Binding Protein 1A Biology urologic and male genital diseases Bone morphogenetic protein Bioinformatics medicine.disease Biochemistry medicine.anatomical_structure FKBP Bmp signaling Drug Discovery medicine Molecular Medicine Molecular Biology Signal Transduction |
| Zdroj: | Cell Chemical Biology. 28:1253-1255 |
| ISSN: | 2451-9456 |
| Popis: | Bone morphogenetic protein (BMP) signaling contributes to acute kidney injury (AKI), a common disease without adequate treatment options. In this issue of Cell Chemical Biology, Larraufie, Gao and colleagues (Larraufie et al., 2021) show that FKBP12 inhibition can be a target for treatment of AKI via activation of BMP signaling. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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