Neutrophil migration into the placenta: Good, bad or deadly?
| Autor: | Bibin Y Subramanian, Shane Vontelin van Breda, Sinuhe Hahn, Irene Hoesli, Paul Hasler, Olav Lapaire, Stavros Giaglis, Nandor Gabor Than, Maria Stoikou, Franco Grimolizzi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Spiral artery Neutrophils Placenta Review Models Biological recurrent fetal loss Preeclampsia preeclampsia Sepsis 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Cell Movement Pregnancy medicine Animals parturition 030219 obstetrics & reproductive medicine business.industry animal model Decidua Pregnancy Outcome neutrophil extracellular traps (NETs) Cell Biology Neutrophil extracellular traps Intervillous space medicine.disease Immunity Innate 030104 developmental biology medicine.anatomical_structure Immunology Female business |
| Zdroj: | Cell Adhesion & Migration |
| ISSN: | 1933-6926 1933-6918 |
| DOI: | 10.1080/19336918.2016.1148866 |
| Popis: | Almost 2 decades have passed since the discovery that pregnancy is associated with a basal inflammatory state involving neutrophil activation, and that this is more overt in cases with preeclampsia, than in instances with sepsis. This pivotal observation paved the way for our report, made almost a decade ago, describing the first involvement of neutrophil extracellular traps (NETs) in a non-infectious human pathology, namely preeclampsia, where an abundance of these structures were detected directly in the placental intervillous space. Despite these remarkable findings, there remains a paucity of interest among reproductive biologists in further exploring the role or involvement of neutrophils in pregnancy and related pathologies. In this review we attempt to redress this deficit by highlighting novel recent findings including the discovery of a novel neutrophil subset in the decidua, the interaction of placental protein 13 (PP13) and neutrophils in modulating spiral artery modification, as well as the use of animal model systems to elucidate neutrophil function in implantation, gestation and parturition. These model systems have been particularly useful in identifying key components implicated in recurrent fetal loss, preeclampsia or new signaling molecules such as sphingolipids. Finally, the recent discovery that anti-phospolipid antibodies can trigger NETosis, supports our hypothesis that these structures may contribute to placental dysfunction in pertinent cases with recurrent fetal loss. |
| Databáze: | OpenAIRE |
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