Circulating MiR-1290 as a potential diagnostic and disease monitoring biomarker of human gastrointestinal tumors
| Autor: | Xu Liyi, Yangke Cai, Jian-Ting Cai, Zhu Yongliang, Xiao Chen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
Lymphovascular invasion Colorectal cancer miR-1290 Mice Nude Apoptosis Mice Surgical oncology Pancreatic cancer Diagnosis Genetics medicine Biomarkers Tumor Tumor Cells Cultured Circulating miRNA Animals Humans Gastrointestinal cancer RC254-282 Cell Proliferation Gastrointestinal Neoplasms Mice Inbred BALB C Surveillance business.industry Gastrointestinal tumor Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Biomarker medicine.disease Prognosis Xenograft Model Antitumor Assays Gene Expression Regulation Neoplastic Survival Rate MicroRNAs Oncology Tumor progression Case-Control Studies Cancer research Biomarker (medicine) Female business Research Article |
| Zdroj: | BMC Cancer BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021) |
| ISSN: | 1471-2407 |
| Popis: | Background Gastrointestinal tumors are a leading cause of mortality worldwide. As shown in our previous study, miR-1290 is overexpressed in colorectal cancer (CRC) and promotes tumor progression. We therefore aimed to explore the potential of circulating miR-1290 as a biomarker for gastrointestinal cancer. Methods A serum miRNA sequencing analysis was performed. Then, circulating miRNA detection technologies were established. The expression of miR-1290 was analyzed in gastrointestinal tumor cell lines and culture supernatants. Expression levels of circulating miR-1290 in clinical samples were examined. Associations between miR-1290 expression and clinicopathologic characteristics were analyzed. Xenograft models were generated to assess the fluctuation in serum miR-1290 levels during disease progression. Results Through miRNA sequencing, we identified that miR-1290 was overexpressed in serum samples from patients with CRC. We confirmed that human gastrointestinal tumor cells express and secrete miR-1290. The circulating miR-1290 levels was up-regulated in patients with pancreatic cancer (PC) (p p p Conclusions Our findings indicate that circulating miR-1290 is a potential biomarker for gastrointestinal cancer diagnosis and monitoring. |
| Databáze: | OpenAIRE |
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