Serum albumin to globulin ratio is related to cognitive decline via reflection of homeostasis: a nested case-control study

Autor: Nagato Kuriyama, Isao Watanabe, Takashi Kasai, Yoshiyuki Watanabe, Toshiki Mizuno, Yoichi Ohshima, Aiko Tamura, Shigeto Mizuno, Kazuo Takeda, Tomokatsu Yoshida, Takahiko Tokuda, Masaki Kondo, Teruhide Koyama, Kei Yamada, Sanae Matsumoto, Masanori Nakagawa, Daisuke Matsui, Ikuko Mizuta, Fumitaro Miyatani, Etsuko Ozaki
Jazyk: angličtina
Předmět:
Male
Aging
medicine.medical_specialty
Serum albumin
Clinical Neurology
Cognitive decline
Neuropsychological Tests
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Homeostatic alteration
medicine
Homeostasis
Humans
Cognitive Dysfunction
Mini-mental state examination
Serum Albumin
Aged
Mini–Mental State Examination
Helicobacter pylori
medicine.diagnostic_test
biology
business.industry
Globulins
General Medicine
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Albumin to globulin ratio
C-Reactive Protein
Case-Control Studies
Nested case-control study
Immunology
Arterial stiffness
biology.protein
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Dyslipidemia
Research Article
Zdroj: BMC Neurology
ISSN: 1471-2377
DOI: 10.1186/s12883-016-0776-z
Popis: Background Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD. Methods A total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD. Results Among CD predictive risk factors, Helicobacter pylori seropositivity was significantly predictive of CD risk, more so than classical risk factors, including white matter lesions and arterial stiffness [adjusted odds ratio (OR) = 4.786, 95% confidence interval (CI) = 1.710–13.39]. A multivariate analysis indicated that the albumin to globulin (A/G) ratio was the only factor that significantly lowered CD risk (OR = 0.092, 95% CI = 0.010–0.887). A/G ratio also was positively correlated with MMSE scores and negatively correlated with disruption of homeostatic factors (i.e., non-high-density lipoprotein, hemoglobin A1c, and high-sensitive C-reactive protein). Conclusions The current study results suggest that the A/G ratio is related to cognitive decline and may reflect homeostatic alterations.
Databáze: OpenAIRE
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