Final Demonstration of the Co-Identity of Lipiarmycin A3 and Tiacumicin B (Fidaxomicin) through Single Crystal X-ray Analysis
Autor: | Piera Fonte, Angelo Bedeschi, Luciana Malpezzi, Stefano Serra, Claudio Fuganti |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Microbiology (medical) Stereochemistry Chemical structure 030106 microbiology 01 natural sciences Biochemistry Microbiology Article Tiacumicin B law.invention Crystal Lipiarmycin A3 03 medical and health sciences actinomycetes antibiotic fidaxomicin lipiarmycin A3 tiacumicin B X-ray analysis law Actinomycetes Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Crystallization X ray analysis 010405 organic chemistry Chemistry lcsh:RM1-950 Antibiotic Absolute configuration 0104 chemical sciences Crystallography lcsh:Therapeutics. Pharmacology Infectious Diseases Single crystal Fidaxomicin |
Zdroj: | Antibiotics; Volume 6; Issue 1; Pages: 7 Antibiotics (Basel) 6 (2017). doi:10.3390/antibiotics6010007 info:cnr-pdr/source/autori:Serra S.; Malpezzi L.; Bedeschi A.; Fuganti C.; Fonte P./titolo:Final demonstration of the co-identity of lipiarmycin A3 and tiacumicin B(Fidaxomicin) through single crystal X-ray analysis/doi:10.3390%2Fantibiotics6010007/rivista:Antibiotics (Basel)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:6 Antibiotics Antibiotics, Vol 6, Iss 1, p 7 (2017) |
ISSN: | 2079-6382 |
DOI: | 10.3390/antibiotics6010007 |
Popis: | Lipiarmycin A3 and tiacumicin B possess the same chemical structure and have been considered identical till recently, when some authors have suggested the possibility of a minor difference between the chemical structures of the two antibiotics. In this work we performed a comparative X-ray analysis of lipiarmycin A3 and tiacumicin B. Although the commercial samples of the aforementioned compounds crystallize into two different crystal systems—evidently due to the different crystallization conditions—their chemical structures are identical. These results confirmed the previous assigned chemical structure of lipiarmycin A3 and its absolute configuration as well as its co-identity with the chemical structure of tiacumicin B, providing the definitive proof that these pharmaceutical compounds are identical in all respects. |
Databáze: | OpenAIRE |
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