Persistent Purine Metabolic Abnormality Induces the Aggravation of Visceral Inflammation and Intestinal Microbiota Dysbiosis in Magang Goose
| Autor: | Heng Wang, Jiangfan Qin, Zhenping Lin, Yujie Zhao, Wence Wang, Hui Ye, Weiqing Ma, Yongwen Zhu, Junpeng Chen, Yang Fu, Xianzhi Jiang, Xiufen Zhang, Li Yu, Huiquan Jiang, Lingjuan Zhou, Lin Yang, Shanshan Zhu, Chen Jianying, Daiyang Xia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Purine
intestinal microbiota Veterinary medicine Physiology Magang goose Inflammation purine metabolic Biology visceral inflammation Jejunum chemistry.chemical_compound Goose gout biology.animal SF600-1100 medicine Hyperuricemia Purine metabolism Original Research General Veterinary medicine.disease Gout medicine.anatomical_structure chemistry Veterinary Science medicine.symptom Dysbiosis |
| Zdroj: | Frontiers in Veterinary Science, Vol 8 (2021) Frontiers in Veterinary Science |
| ISSN: | 2297-1769 |
| DOI: | 10.3389/fvets.2021.737160/full |
| Popis: | Gout is a disease involving abnormal purine metabolism that is widespread in mammals and birds. Goose is especially susceptible for gout in early stage. However, a few studies investigated the ontogenetic pattern of goslings with purine metabolic abnormality. Our studies were conducted to investigate whether persistent purine metabolic abnormality would lead to aggravation of visceral inflammation and intestinal microbiota dysbiosis in goose. A total of 132 1-day-old Magang geese were randomly divided into six replicates and fed a high-calcium and protein meal-based diet from 1 to 28 days. The experiment lasted for 28 days. Liver and kidney damages were observed in 14- and 28-day-old Magang geese, and liver inflammation increased with increasing age. In 28-day-old Magang geese, serum CAT and liver GSH-Px activity were significantly reduced. Furthermore, jejunum intestinal barrier was impaired and the abundance of Bacteroides was significantly reduced at the genus level. Collectively, the high-calcium and high-protein (HCP) meal-based diet caused liver and kidney damage in 28-day-old Magang geese, leading to hyperuricemia and gout symptoms, and the intestinal barrier is impaired and the intestinal flora is disrupted. |
| Databáze: | OpenAIRE |
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