Analysis of thin-section CT in patients with coronavirus disease (COVID-19) after hospital discharge

Autor: Yingying Qiu, Bingliang Zeng, Chengfeng Wan, Pinggui Lei, Hong Yang, Peng Yu, Yinchao Jian, Jian Lv, Bing Fan, Jiangping Wei
Rok vydání: 2020
Předmět:
Adult
Male
Thorax
medicine.medical_specialty
Pulmonary Fibrosis
Pneumonia
Viral
coronavirus
X-ray computed
severe acute respiratory syndrome
Disease
tomography
Gastroenterology
Group B
030218 nuclear medicine & medical imaging
law.invention
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Fibrosis
law
Internal medicine
Pulmonary fibrosis
medicine
Humans
Radiology
Nuclear Medicine and imaging
Electrical and Electronic Engineering
Lung
Pandemics
Instrumentation
Aged
Retrospective Studies
Radiation
SARS-CoV-2
business.industry
COVID-19
Retrospective cohort study
Middle Aged
Condensed Matter Physics
medicine.disease
Intensive care unit
Patient Discharge
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Coronavirus Infections
Tomography
X-Ray Computed
business
Research Article
Zdroj: Journal of X-Ray Science and Technology
ISSN: 1095-9114
0895-3996
Popis: PURPOSE: To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital discharge. MATERIALS AND METHODS: Fifty-nine patients (31 males and 28 females ranging from 25 to 70 years old) with confirmed COVID-19 infection performed follow-up thin-section thorax CT. After 31.5±7.9 days (range, 24 to 39 days) of hospital admission, the results of CT were analyzed for parenchymal abnormality (ground-glass opacification, interstitial thickening, and consolidation) and evidence of fibrosis (parenchymal band, traction bronchiectasis, and irregular interfaces). Patients were analyzed based on the evidence of fibrosis and divided into two groups namely, groups A and B (with and without CT evidence of fibrosis), respectively. Patient demographics, length of stay (LOS), rate of intensive care unit (ICU) admission, peak C-reactive protein level, and CT score were compared between the two groups. RESULTS: Among the 59 patients, 89.8% (53/59) had a typical transition from early phase to advanced phase and advanced phase to dissipating phase. Also, 39% (23/59) patients developed fibrosis (group A), whereas 61% (36/59) patients did not show definite fibrosis (group B). Patients in group A were older (mean age, 45.4±16.9 vs. 33.8±10.2 years) (P = 0.001), with longer LOS (19.1±5.2 vs. 15.0±2.5 days) (P = 0.001), higher rate of ICU admission (21.7% (5/23) vs. 5.6% (2/36)) (P = 0.061), higher peak C-reactive protein level (30.7±26.4 vs. 18.1±17.9 mg/L) (P = 0.041), and higher maximal CT score (5.2±4.3 vs. 4.0±2.2) (P = 0.06) than those in group B. CONCLUSIONS: Pulmonary fibrosis may develop early in patients with COVID-19 after hospital discharge. Older patients with severe illness during treatment were more prone to develop fibrosis according to thin-section CT results.
Databáze: OpenAIRE
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