Rational use of trastuzumab in metastatic and locally advanced breast cancer: Implications of recent research
| Autor: | Michael Michael, Prudence A. Francis, Shom Goel, J. Dewar, Jacquie Chirgwin, Raymond Snyder, Bogda Koczwara, Linda Mileshkin, Robin Stuart-Harris |
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| Rok vydání: | 2011 |
| Předmět: |
Oncology
medicine.medical_specialty Receptor ErbB-2 Antineoplastic Agents Breast Neoplasms Antibodies Monoclonal Humanized Lapatinib Inflammatory breast cancer Breast cancer Recurrence Trastuzumab Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Metastasis skin and connective tissue diseases neoplasms business.industry Antibodies Monoclonal Cancer General Medicine medicine.disease Metastatic breast cancer Neoadjuvant Therapy Clinical trial Regimen Chemotherapy Adjuvant Drug Resistance Neoplasm Disease Progression Female Surgery business medicine.drug |
| Zdroj: | The Breast. 20:101-110 |
| ISSN: | 0960-9776 |
| Popis: | The management of HER2-positive metastatic breast cancer, a disease renowned for its aggressive natural history, has been revolutionized by the introduction of trastuzumab. Indeed, outcomes for patients with HER2-positive advanced breast cancer are now equivalent to, if not better than, those of their HER2-negative counterparts. Since the pivotal registration trial, a wealth of new clinical data has emerged regarding the use of trastuzumab in a variety of clinical contexts - adding to the evidence but also highlighting areas of uncertainly and debate. These include the optimal partner chemotherapy(ies) to trastuzumab; the effectiveness of combining trastuzumab with endocrine therapy; the benefits of continuing trastuzumab after progression on a trastuzumab-containing regimen; and the role of trastuzumab in locally advanced and inflammatory breast cancer. In this paper we review major clinical trials addressing these questions, clinical recommendations that can be made as a result, and the strength of evidence that supports them. Finally, we identify areas of ongoing uncertainty, and propose recommendations for future research in this field. |
| Databáze: | OpenAIRE |
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