Regulation of porcine biliary secretion by secretin
Autor: | O. Olsen, O B Schaffalitzky de Muckadell, T. Houe, N. J. Andersen, P. Svendsen, S. S. Sætre, J. F. Rehfeld |
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Rok vydání: | 1998 |
Předmět: |
medicine.medical_specialty
Physiology Duodenum Swine Bicarbonate digestive system Secretin Gastric Acid chemistry.chemical_compound Eating fluids and secretions Internal medicine medicine Animals Bile Chemistry Portal Vein digestive system diseases Hormones Pentagastrin Bicarbonates Endocrinology Postprandial medicine.anatomical_structure Gastrointestinal hormone Liver Biliary tract Injections Intravenous Gastric acid Swine Miniature Female Hydrochloric Acid hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Acta physiologica Scandinavica. 163(1) |
ISSN: | 0001-6772 |
Popis: | The importance of physiological plasma levels of secretin in biliary bicarbonate secretion is not known. However, in anaesthetized pigs the substantial hepatic output of bicarbonate into the duodenum in response to low doses of secretin exceeds pancreatic bicarbonate output. The aim was therefore to study the relationship between duodenal acidification, secretin and hepatic biliary bicarbonate output in the conscious pig. Gottingen minipigs (n = 22) were cholecystectomized and the common bile duct catheterized. The biliary bicarbonate secretion in response to intraduodenal HCl, secretin or pentagastrin given intravenously, and to meal was studied. Intraduodenal HCl infusion, secretin and pentagastrin given intravenously augmented hepatic bicarbonate output and plasma secretin concentrations significantly. The secretin response to acidification was sufficient to explain the subsequent increase in biliary bicarbonate secretion. Hepatic bicarbonate secretion and concentrations of CCK and secretin in plasma increased postprandially. Exclusion of bile salts from the duodenum abolished postprandial increase in bile volume and increased release of CCK in fasting and fed pigs whereas secretin release was diminished. The results demonstrate that hepatic bicarbonate secretion is stimulated by endogenous secretin and therefore may have a physiological role in duodenal neutralization. |
Databáze: | OpenAIRE |
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