Association between BHMT and CBS gene promoter methylation with the efficacy of folic acid therapy in patients with hyperhomocysteinemia
| Autor: | Binghui Du, Chengda Zhang, Dankang Li, Xiliang Wang, Opolot Godfrey, Qinglin Zhao, Xiaowen Huang, Weidong Zhang, Bingnan Ren, Limin Yue |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Hyperhomocysteinemia Cystathionine beta-Synthase 030105 genetics & heredity Methylation 03 medical and health sciences Folic Acid Internal medicine Genetics Humans Medicine Prospective Studies Promoter Regions Genetic Prospective cohort study Gene Genetics (clinical) Aged chemistry.chemical_classification biology business.industry Promoter Metabolism Middle Aged medicine.disease Cystathionine beta synthase 030104 developmental biology Endocrinology Enzyme Betaine-Homocysteine S-Methyltransferase chemistry biology.protein Female business |
| Zdroj: | Journal of Human Genetics. 64:1227-1235 |
| ISSN: | 1435-232X 1434-5161 |
| DOI: | 10.1038/s10038-019-0672-7 |
| Popis: | Both betaine homocysteine methyltransferase (BHMT) and cystathionine β-synthase (CBS) are major enzymes in the metabolism of plasma homocysteine (Hcy). Abnormal methylation levels of BHMT and CBS are positively associated with Hcy levels. The present study is performed to explore the association between the methylation levels in the promoter regions of the BHMT and CBS genes and the efficacy of folic acid therapy in patient with hyperhomocysteinemia (HHcy). A prospective cohort study recruiting HHcy (Hcy ≥ 15 μmol/L) patients was performed. The subjects were treated with oral folic acid (5 mg/d) for 90 days, and the patients were divided into the success group (Hcy |
| Databáze: | OpenAIRE |
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