Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom
| Autor: | Ghafaryasl, Babak, Vermeer, Koenraad A., Kalkman, J., Callewaert, Tom, De Boer, Johannes F., Van Vliet, Lucas J., Izatt, Joseph A., Fujimoto, James G., Tuchin, Valery V. |
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| Přispěvatelé: | Biophotonics and Medical Imaging, Amsterdam Neuroscience - Brain Imaging, LaserLaB - Biophotonics and Microscopy, Izatt, Joseph A., Fujimoto, James G., Tuchin, Valery V. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Point spread function
Rayleigh length Physics::Medical Physics 01 natural sciences Signal beam-shape Imaging phantom 010309 optics focus 03 medical and health sciences 0302 clinical medicine Optics Optical coherence tomography 0103 physical sciences medicine attenuation coefficient SDG 7 - Affordable and Clean Energy Physics Spectrometer medicine.diagnostic_test business.industry Detector point spread function OCT Attenuation coefficient Cramér-Rao lower bound 030221 ophthalmology & optometry business Focus (optics) |
| Zdroj: | Proceedings of SPIE: Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII, 10483 Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII Ghafaryasl, B, Vermeer, K A, Kalkman, J, Callewaert, T, De Boer, J F & Van Vliet, L J 2018, Accurate estimation of the attenuation coefficient from axial point spread function corrected OCT scans of a single layer phantom . in J A Izatt, J G Fujimoto & V V Tuchin (eds), Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII ., 104832B, Proceedings, vol. 10483, SPIE, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXII 2018, San Francisco, United States, 29/01/18 . https://doi.org/10.1117/12.2292002 |
| DOI: | 10.1117/12.2292002 |
| Popis: | The attenuation coefficient (AC) is a property related to the microstructure of tissue on a wavelength scale that can be estimated from optical coherence tomography (OCT) data. Since the OCT signal sensitivity is affected by the finite spectrometer/detector resolution called roll-off and the shape of the focused beam in the sample arm, ignoring these effects leads to severely biased estimates of AC. Previously, the signal intensity dependence on these factors has been modeled. In this paper, we study the dependence of the estimated AC on the beam-shape and focus depth experimentally. A method is presented to estimate the axial point spread function model parameters by fitting the OCT signal model for single scattered light to the averaged A-lines of multiple B-scans obtained from a homogeneous single-layer phantom. The estimated model parameters were used to compensate the signal for the axial point spread function and roll-off in order to obtain an accurate estimate of AC. The result shows a significant improvement in the accuracy of the estimation of AC after correcting for the shape of the OCT beam. |
| Databáze: | OpenAIRE |
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