Epitope-specific glutamic acid decarboxylase-65 autoantibodies in intravenous immunoglobulin preparations
| Autor: | Connie L. Davis, Åke Lernmark, Wei Hao, Christiane S. Hampe, Terri Daniels |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
endocrine system diseases Glutamate decarboxylase Antibody Affinity Neurological disorder Epitope law.invention Epitopes Antibody Specificity law hemic and lymphatic diseases medicine Humans Autoantibodies chemistry.chemical_classification biology Glutamate Decarboxylase business.industry Autoantibody Immunoglobulins Intravenous nutritional and metabolic diseases Hematology Glutamic acid medicine.disease Recombinant Proteins Isoenzymes Enzyme chemistry Immunology biology.protein Recombinant DNA Antibody business |
| Zdroj: | Transfusion Medicine. 9:307-310 |
| ISSN: | 1365-3148 0958-7578 |
| DOI: | 10.1046/j.1365-3148.1999.00214.x |
| Popis: | Intravenous immunoglobulin (IVIG) has been used to treat many autoimmune disorders including Stiff-Man Syndrome (SMS). SMS is a neurological disorder associated with an immune-mediated deficiency of gamma-aminobutyric acid (GABA) due to autoantibodies against the GABA synthesizing enzyme glutamic acid decarboxylase-65 (GAD65). GAD65 autoantibodies are present among 1-2% of healthy individuals. It can therefore not be excluded that GAD65 autoantibodies may be present in IVIG, which is prepared from multiple blood donors. We report here that GAD65 but not IA-2 autoantibodies were present in commercial IVIG preparations. The presence of autoantibodies may affect the outcome of IVIG treatment and screening commercial preparations of IVIG for GAD65 autoantibodies is therefore recommended before treating patients. |
| Databáze: | OpenAIRE |
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