Molecular mechanisms involved in interleukin 1-beta (IL-1β)-induced memory impairment. Modulation by alpha-melanocyte-stimulating hormone (α-MSH)
| Autor: | Teresa Nieves Scimonelli, Helgi B. Schiöth, Mercedes Lasaga, Carla Mariana Caruso, German A. Roth, Ivana Noelia Machado, Patricia Verónica Gonzalez, Aldo Alejandro Vilcaes |
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| Rok vydání: | 2013 |
| Předmět: |
Male
MAPK/ERK pathway medicine.medical_specialty CIENCIAS MÉDICAS Y DE LA SALUD p38 mitogen-activated protein kinases Neurociencias Interleukin-1beta Immunology Glutamic Acid MEMORY CONSOLIDATION ALPHA-MSH Hippocampus p38 Mitogen-Activated Protein Kinases Behavioral Neuroscience chemistry.chemical_compound Internal medicine Conditioning Psychological medicine Animals Memory impairment Rats Wistar IL-1BETA GLUTAMATE RELEASE Extracellular Signal-Regulated MAP Kinases Memory Disorders Endocrine and Autonomic Systems Glutamate receptor P38 Long-term potentiation Fear alpha-Melanocyte-stimulating hormone ERK Medicina Básica BDNF Endocrinology chemistry alpha-MSH NMDA receptor Memory consolidation Psychology Neuroscience |
| Zdroj: | Brain, Behavior, and Immunity. 34:141-150 |
| ISSN: | 0889-1591 |
| Popis: | Pro-inflammatory cytokines can affect cognitive processes such as learning and memory. Particularly, interleukin-1β (IL-1β) influences the consolidation of hippocampus-dependent memories. We previously reported that administration of IL-1β in dorsal hippocampus impaired contextual fear memory consolidation. Different mechanisms have been implicated in the action of IL-1β on long-term potentiation (LTP), but the processes by which this inhibition occurs in vivo remain to be elucidated. We herein report that intrahippocampal injection of IL-1β induced a significant increase in p38 phosphorylation after contextual fear conditioning. Also, treatment with SB203580, an inhibitor of p38, reversed impairment induced by IL-1β on conditioned fear behavior, indicating that this MAPK would be involved in the effect of the cytokine. We also showed that IL-1β administration produced a decrease in glutamate release from dorsal hippocampus synaptosomes and that treatment with SB203580 partially reversed this effect. Our results indicated that IL-1β-induced impairment in memory consolidation could be mediated by a decrease in glutamate release. This hypothesis is sustained by the fact that treatment with d-cycloserine (DCS), a partial agonist of the NMDA receptor, reversed the effect of IL-1β on contextual fear memory. Furthermore, we demonstrated that IL-1β produced a temporal delay in ERK phosphorylation and that DCS administration reversed this effect. We also observed that intrahippocampal injection of IL-1β decreased BDNF expression after contextual fear conditioning. We previously demonstrated that α-MSH reversed the detrimental effect of IL-1β on memory consolidation. The present results demonstrate that α-MSH administration did not modify the decrease in glutamate release induced by IL-1β. However, intrahippocampal injection of α-MSH prevented the effect on ERK phosphorylation and BDNF expression induced by IL-1β after contextual fear conditioning. Therefore, in the present study we determine possible molecular mechanisms involved in the impairment induced by IL-1β on fear memory consolidation. We also established how this effect could be modulated by α-MSH. Fil: Gonzalez, Patricia Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Machado, Ivana Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina Fil: Vilcaes, Aldo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina; Argentina Fil: Caruso, Carla Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Biomedicas; Argentina; Argentina Fil: Roth, German Alfredo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Química Biológica de Córdoba (p); Argentina; Argentina Fil: Schiöth, H.. Uppsala University; Suecia Fil: Lasaga, Mercedes Isabel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Investigaciones Biomedicas; Argentina; Argentina Fil: Scimonelli, Teresa Nieves. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto de Farmacología Experimental de Córdoba; Argentina |
| Databáze: | OpenAIRE |
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